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Recent Publications

Hülya Bükülmez   Arnold I. Caplan   Diego Correa   Jonathan Kenyon   Donald P. Lennon   Rodrigo A. Somoza   J. Michael Sorrell   Jean F. Welter

 

Tissue Engineering
Figure from: “Chou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering, Part A 2013, 19(9-10):1081 – 1090.” Abstract Selected as cover art for “Tissue Engineering Part A – 2013”.

 

Hülya Bükülmez, M.D.

Bükülmez, H.; Khan, F,; Bartels, C.F.; Murakami, S.; Ortiz-Lopez, A.; Sattar, A.; Haqqi, T.M.; and Warman, M.L.: Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in an inflammatory arthritis mouse model. Arthritis Rheum. 2013 Sep 24. doi: 10.1002/art.38199. [Epub ahead of print] Abstract
See supplemental data for this paper here

Bükülmez, H.; Wargula, J.; Bove, K.; Lovell, D.; and Griffin, T.: High dose corticosteroids may aggravate the vasculopathy that underlies ulcerative juvenile dermatomyositis. Journal of Rheumatology. (In Press)

Matsushita, T.; Wilcox, W.R.; Chan, Y.Y.; Kawanami, A.; Bükülmez, H.; Balmes, G.; Krejci, P.; Mekikian, P.B.; Otani, K.; Yamaura, I.; Warman, M.L.; Givol, D.; and Murakami, S.: FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Human Molecular Genetics 2009 18(2):227-240. Abstract

Miles L, Bove KE, Lovell D, Wargula JC, Bükülmez, H., Shao, M.; Salisbury, S.; and Bean, J.A.: Predictability of the clinical course of juvenile dermatomyositis based on initial muscle biopsy: a retrospective study of 72 patients. Arthritis and Rheumatism 2007 Oct 15; 57(7):1183-91. Abstract

 

Arnold I. Caplan, Ph.D.

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 pii: S0165-2478(15)00103-0. doi: 10.1016/j.imlet.2015.06.005. [Epub ahead of print] Abstract

Caplan, A.I.: Adult mesenchymal stem cells and women’s health. Menopause. 2015 (2):131-135. Abstract

Adorno-Cruz, V.; Kibria, G.; Liu, X.; Doherty, M.; Junk, D.J.; Guan, D.; Hubert, C.G.; Venere, M.; Mulkearns-Hubert, E.; Sinyuk, M.; Alvarado, A.; Caplan, A.I.; Rich, J.N.; Gerson, S.L.; Lathia, J.D.; and Liu, H.: Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015 pii: canres.3225.2014 Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage. 2015 23(3):443-53. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue Engineered Constructs for a Canine Critical Size Cranial Defect. Acta Biomaterialia, Submitted 2012.

Sorrell, J.M. and Caplan, A.I.: Mesenchymal stem cells in skin and in the role of mesenchymal stem cells in cutaneous wound repair. J Invest Dermatol, (Submitted).

Bonfield, T.L.; Lennon, D.; and Caplan, A.I.: Human mesenchymal stem cells resolve infection and inflammation in pseudomonas aeruginosa infected cystic fibrosis transmembrane receptor knockout mice. Am J Physiol Lung Cell Mol Physiol, Submitted 2012.
Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract

Murphy, M.B.; Moncivais, K.; and Caplan, A,I.: Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013 15;45:e54. doi: 10.1038/emm.2013.94. Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2014 22(1):160-168. Abstract

Dimarino, A.M.; Caplan, A.I.; and Bonfield, T.L.: Mesenchymal Stem Cells in Tissue Repair. Front Immunol. 2013 Sep 4;4:201. Review. Abstract

Kean, T.J.; Lin, P.; Caplan, A.I.; and Dennis, J.E.: MSCs: Delivery routes and engraftment, cell-targeting strategies, and immune modulation. Stem Cells Int. 2013;2013:732742. doi: 10.1155/2013/732742. Epub 2013 Aug 13. Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 Jul;34(23):5802-12 Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Eng, M.; Lennon, D.P.; Caplan, A.I.; and Bruder, A.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 Jun 10;319(10):1409-18. Abstract

Caplan, A.: MSCs as Therapeutics. In: Stem Cell Biology and Regenerative Medicine. Mesenchymal Stromal Cells: Biology and Clinical Applications, Stem Cell Biology and Regenerative Medicine. Hematti, P. and Keating, A. (Eds.), Springer Science+Business Media New York, Chapter 5. Accepted 2012.

Caplan, A.I.: MSCs: The New Medicine (invited chapter) In: Stem Cells in Regenerative Medicine: Science, Regulation, and Business Strategies. A Vertes (Eds), John Wiley & Sons, Ltd, Accepted 2012.

Caplan, A.I.: Mesenchymal Stem Cells in Regenerative Medicine. In: Handbook of Stem Cells, Vol 2, eds A Atala and R Lanza, eds. Academic Press, Chapter 43, Pp. 493-502 , 2012.
da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: Pericytes as the source of mesenchymal stem cells. In: Resident Stem Cells and Regenerative Therapy, Goldenberg, R.C. and de Carvalho, A.C.C., eds. Elsevier Inc. Chapter 12, Pp. 233-250, 2012.

Caplan, A.I.: Adult mesenchymal stem cells and the NO pathways. Proceedings of the National Academy of Science U S A. 2013 110(8):2695-16956. Link

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. 2012 [Epub ahead of print] Abstract

Dong, F. and Caplan, A.I.: Cell transplantation as an initiator of endogenous stem cell-based tissue repair. Curr Opin Organ Transplant. 2012, 17(6):670-4. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract

Lizier, N.F.; Kerkis, A.; Gomes, C.M.; Hebling, J.; Oliveira, C.F.; Caplan, A.I.; and Kerkis, I.” Scaling-up of dental pulp stem cells isolated from multiple niches. PLoS One. 2012;7(6):e39885. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract

Carrino, D.A.; Mesiano, S.; Barker, N.M.; Hurd, W.W.; and Caplan, A.I.: Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J. 2012, 443(2):361-8. Abstract

Kerkis, I. and Caplan, A.I.: Stem cells in dental pulp of deciduous teeth. Tissue Eng Part B Rev. 2012, 18(2):129-38. Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Ann Biomed Eng. 2011, 39(10):2521-30 Abstract

Pineau, N.; Carrino, D.A.; Caplan, A.I.; and Breton, L.: Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. Eur J Dermatol. 2011, 21(3):359-70. Abstract

Singer, N.G. and Caplan, A.I.: Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol. 2011, 28;6:457-78. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.P.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol. 2010, 299(6):L760-70. Abstract

Caplan, A.I.: What’s in a name? Tissue Eng Part A. 2010, 16(8):2415-7.

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan, A.I.: Acute asthma: An in vivo model for human mesenchymal stem cell efficacy. J. Immunol Methods. Submitted 2009.

Bonfield, T.L. and Caplan, A.I.: Adult mesenchymal stem cells: An innovative therapeutic for lung diseases. Discov Med. 2010, 9(47):337-45. Abstract

Abrahamsson, C.; Yang, F.; Park, H.; Brunger, J.; Valonen, P.; Langer, R.; Welter, J.; Caplan, A.; Guilak, F.; and Freed L.: Chondrogenesis and mineralization with in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds, Tissue Engineering Part A. 2010, 16(12):3709-18. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discovery Medicine, 9(46):236-42. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Diekman, B.O.; Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: Chondrogenesis of adult stem cells from adipose tissue and bone marrow: Induction by growth factors and cartilage derived matrix. Tiss Eng, Part A, 523-533, 2010

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Influence of Adult Mesenchymal Stem Cells on In Vitro Vascular Formation. In: Advances in Tissue Engineering, Volume 1: Angiogenesis. Chapter 24, Pp. 241-248, 2010.

Caplan, A.I.: Mesenchymal stem cells: The past, the present, the future. Cartilage 1(1)6-9, 2010.

Caplan, A.I.: New era of cell-based orthopaedic therapies. Tissue Engineering, Part B, 15(2):195-200, 2009. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

Bai, V.L.; Lennon, D.P.; Eaton, V.; Maier, K.; Caplan, A.I.; Miller, S.D.; and Miller, R.H.: Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia, Epub ahead of print 2009. Abstract

Caplan, A.I.: Why are MSCs therapeutic? New data: new insight. Journal of Pathology, 217:318-324, 2009. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I,: Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering Part A, Volume 15, Epub ahead of print, 2009. Abstract

Malinin, N.L.; Zhang, L.; Choi, J.; Ciocea, A.; Razorenova, O.; Ma, Y.Q.; Podrez, E.A.; Tosi, M.; Lennon, D.P,; Caplan, A.I.; Shurin, S.B.; Plow, E.F.; and Byzova, T.V.: A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Medicine, 15:313-318, 2009. Abstract

Park, H.; Guo, X.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Kasper, F.K.; and Mikos, A.G.: Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules, 10:541-546, 2009. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; Raphael, R.M.; Jansen, J.A.; and Mikos, A.G.: Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of Biomedical Materials Research, Part A, 88(4):889-897, 2009. Abstract

Song, I.H.; Caplan, A.I. and Dennis, J.E.: Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of Orthopaedic Research, 27(2):216-221, 2009. Abstract

da Silva Meirelles, L.; Sand,T.T.; Harman, R.J.; Lennon, D.P.; Caplan, A.I.: MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue Engineering, Part A 15(2): 221-229, 2009.

Sorrell, J.M. and Caplan, A.I.: Fibroblasts – A diverse population at the center of it all. International Review of Cell and Molecular Biology, (Submitted), 2009.

Butler, D.L; Lewis, J.F.; Frank, C.B; Banes, A.J.; Caplan, A.I.; de Deyne, P.G. et al.: Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: A conference report. Tissue Engineering, Part A 14(12): 2089-2104, 2008.
Grayson, W.L.; Bhumiratana, S.; Canizzarro, C.; Chao, P.G.; Lennon, D.P; Caplan, A.I.; and Vunjak-Novakovic, G.: Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Engineering, Part A: 14(11):1809-1820, 2008. Abstract

Caplan, A.I.: All MSCs are pericytes? Cell Stem Cell, 3(3):229-30, 2008. Abstract

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: The mesenchymal stem cell niche. 2007 (Submitted).

da Silva Meirelles, L.; Caplan, A.I.; and Nardi, N.B.: In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26:2287-2299, 2008. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound Repair & Regeneration 2008, 16(2):300-9. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007, 186:157-168. Abstract

Caplan, A.I.: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of Cell Physiology 2007, 213:341-347. Abstract

Gao, J.; Yao, J.Q.; and Caplan, A.I.: Stem cells for tissue engineering of articular cartilage. Proceedings of the Institute of Mechanical Engineers 2007, 221:441-450. Abstract

Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocyte from three anatomic locations in the rabbit. Tissue Engineering 2007, 13:843-853. Abstract

Park, H.; Temenoff, J.S.; Tabata, Y.; Caplan, A.I.; and Mikos, A.G.: Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 2007, 28:3217-3227. Abstract

Kerkis, I.; Kerkis, A.; Dozortsev, D.; Stukart-Parsons, G.C.; Gomes-Massironi, S.M.; Pereira, L.V.; Caplan, A.I.; and Cerruti, H.F.: Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs 2006, 184(3-4):105-16. Abstract

Bai, L.; Caplan, A.I.; Lennon, D.L.; and Miller, R.H.: Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochemical Research 2007, 32:353-362. Abstract

Sorrell, J.M.; Baber, M.A.; and Caplan, A.I.: Clonal characterization of fibroblasts in the superficial layer of the adult dermis. Cell and Tissue Research 2007, 327:499-510. Abstract

 

Diego Correa, M.D., M.Sc., Ph.D.

Correa, D.; Lin, P.; Rom, E.; Welter, J.; Duesler, L.; Yayon, A.; and Caplan. A.I.: Sequential stimulation with Fibroblast growth factors (FGFs) 2, 9 and 18 Regulate the Ultimate Phenotype of MSC-derived Chondrocytes. Osteoarthritis and Cartilage, 2014 (In press)
Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2013 Sep 25. doi: 10.1038/mt.2013.221. [Epub ahead of print] Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Correa, D. and Segal, S.S.: Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation. 2012 May;19(4):306-15. doi: 10.1111/j.1549-8719.2012.00163.x. Abstract

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press) Abstract

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.

Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal; 25(9): 3057-3067. Abstract

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010, 191(7):1271-1283. Abstract

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010, 19(4):533-546. Abstract

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010, 1192:32-37. Abstract

 

Jonathan E. Kenyon, Ph.D.

Kenyon, J.; Fu, P.; Lingas, K.; Thomas, E.; Saurastri, A.; Santos Guasch, G.; Wald, D.; and Gerson, S.L.: Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012; 120(16):3229-36. Abstract

 

Donald P. Lennon, D.D.S.

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue Engineered Constructs for a Canine Critical Size Cranial Defect. Acta Biomaterialia, Submitted 2012.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. 2014 Biofabrication 2014, 6(1):015003. doi: 10.1088/1758-5082/6/1/015003 Abstract

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 34(23):5802-12. Abstract

Crapnell, K.; Blaesius, R.; Hastings, A.; Lennon, D.P.; Caplan, A.I; and Bruder, S.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 319(10):1409-18.Abstract

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond). 2010, 25;7:51. Abstract

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010, 9(46):236-42. Abstract

Rodrigo A. Somoza, Ph.D.

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. Journal of Experimental medicine, (2014) (submitted).

Somoza, R.A; Acevedo, C.A.; Weinstein-Oppenheimer, C.; Luz, P.A.; Carrión, F.; and Young, M.E.: TGF-ß3 secretion by human dental follicle mesenchymal stem cells (hDF-MSC) encapsulated in alginate and fibrin scaffolds. Journal of Tissue Engineering and Regenerative Medicine 2014 (in revision).

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of mesenchymal stem cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract

Acevedo, C.A.; Somoza, R.A.; Weinstein-Oppenheimer, C.; Silva, A.; Moreno, M.; Sanchez, E.; Albornoz, F.; Young, M.E.; MacNaughtan, W.; and Enrione, J. Improvement of human skin cells growth by radiation induced modifications of a Ge/Ch/Ha-scaffold. Bioprocess Biosyst Eng 2013 36:317–324. Abstract

Somoza, R.A. and Rubio, F.J: Cell therapy using induced pluripotent stem cells or somatic stem cells: this is the question. Current Stem Cell Research and Therapy. 2012 7(3):191-196. Abstract

Somoza, R.; Conget, P.; and Rubio, F.J.: Neuropotency of human mesenchymal stem cell cultures: Clonal studies reveal the contribution of cell plasticity and cell contamination. Biology of Blood and Marrow Transplantation 2012 14:546-555. Abstract

Acevedo, C.; Somoza, R.; Weinstein-Oppenheimer, C.; Brown, D.; and Young, M.: Growth factor production from fibrin-encapsulated human keratinocytes. Biotechnology Letters 2010 32:1011–1017. Abstract

Somoza, R.; Juri, C.; Baes, M; Wyneken, U.; and Rubio, F.J.: Intranigral transplantation of epigenetically-induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson´s disease. Biology of Blood and Marrow Transplantation 2010 16:1530-1540. Abstract

Enrione, J.; Osorio, F.; López, D.; Weinstein-Oppenheimer, C.; Fuentes, M.A.; Cereani, R.; Brown, D.I.; Albornoz, F.; Sánchez, E.; Villalobos, P.; Somoza, R.A.; Young, M.E.; and Acevedo, C.A.: Characterization of a gelatin/chitosan/hyaluronan scaffold-polymer. Electronic Journal of Biotechnology, 2010 DOI: 10.2225/vol13-issue5-fulltext-15.

 

J. Michael Sorrell, Ph.D.

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 pii: S0165-2478(15)00103-0. doi: 10.1016/j.imlet.2015.06.005. [Epub ahead of print] Abstract

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract

 

Jean F. Welter, M.D., M.Sc., Ph.D.

Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering 2015 (Accepted).

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-2300Abstract

Mansour, J.M.; Gu, D.-W.; Chung, C.-Y.; Heebner, J.; Schluchter, M.D.; and Welter, J.F.: Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of Biomedical Engineering 2014 (E-pub ahead of print) Abstract

Correa, D.; Somoza, R.A.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis Cartilage. 2015 23(3):443-53. Abstract

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, 2014 20(6):596-608 Abstract

Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014, (Submitted)

Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring shell thickness in engineered cartilage. (in revision)

Penick, K.J.; Solchaga, L.A.; Caplan A.I.; Goldberg, V.M.; and Welter, J.F.: Epitope retrieval for type X collagen detection. (in revision)

Holt, V.; Welter, J.F.; Berilla, J.A.; Harris, M.; and Caplan, A.I.: Cell capture apparatus and staining device. Provisional patent application number 61/875918 filed September 10, 2013.

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract

Welter, J.F.; Solchaga, L.A.; Berilla, J.A.; and Penick, K.: Apparatus and method for tissue engineering. US Patent # 8,507,266 issued August 13, 2013.

Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013, 33(1):1-16 Abstract

Welter, J.F.; Penick, J.; Solchaga, L.A.: Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique Stem Cells International 2013:806525 Abstract

Bükülmez, H.; Bartels, C.F.; Nanda, K.; Haqqi, T.M.; and Welter, J.F.: Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model. Pediatric Rheumatology 2012, 10(Suppl 1):A109

Chou, C.L.; Rivera, A.L.; Sakai, T.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. Tissue Eng Part A. 2012 [Epub ahead of print] Abstract

Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol. 2012;506:247-63. Abstract

Shao, Y.Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50(1):79-84. Abstract

Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annals of Biomed Eng. 2011, 39(10):2521-30 Abstract

Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346-59 Abstract

Solchaga, L.A., Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. Chapter in: MSC Assays and Applications. Methods in Molecular Biology. Humana Press, 2011:698:253-278. Abstract)

Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract

Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract

Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. Journal of Biomedical Materials Research, Part A 2010 94(4):1050 – 1060. Abstract

Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract

Solchaga, L.A.; Penick, K.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 delays the loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering Part A, 2010 16(3):1009-1019 Abstract

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