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Case Western Reserve University Malaria Study Group
Background
Mosquitoes transmit a wide variety of microbial pathogens in all parts of the world. Without adequate ecological insight, mosquito control efforts are frequently incomplete, and may fall short of meeting programmatic goals to improve public health. The 1955-69 World Health Organization (WHO) malaria eradication program serves as a historical reminder that incomplete anthropogenic attempts to control mosquitoes can actually increase prevalence of disease if unsustained control measures result in partial interruption of human immunity or in the emergence of drug-resistent pathogens and/or insecticide-resistant mosquitoes. Currently, interest is resurfacing in the potential of mosquito-based malaria control through deployment of insecticide-treated bednets (ITN), a feature central to plans articulated by the United Nation's Millennium Development Project, WHO's Roll Back malaria program, and the President's Malaria Initiative. While these programs are certain to gain from prior experience, it is important to acknowledge that study designs for these efforts are based on data dimensions that do not capture landscape variation, mosquito species distribution, or vectors' interactions with the multiple pathogens they transmit. This leads us to an overall hypothesis that control strategies guided by overly generalized landscape and ecological assessments will not be sufficiently effective against all antrhopophagic mosquito species, and will fail to reduce the burden of malaria in high-risk areas. Our overall objective is to provide insight into the fine- and medium-scale factors that contribute to village-by-village risk differences for mosquito-borne parasite transmission, as modified by intercurrent anthropogenic change and other local environmental factors.
Our study takes advantage of a 25-year collaboration between Case Western Reserve University (Case) and Papua New Guinea Institute of Medical Research (PNGIMR), which has extensive expertise in research and training in mosquito-borne diseases.
Links: Basic Biology and Disease
Malaria Blood Smear Diagnosis
Malaria Journal
Comprehensive malaria Site
Malaria title page at Brown
CDC Malaria pages
Wellcome trust Malaria page
MacLean lectures (McGill University)
Data bases and tools
MARA-ARMA project - Mapping Malaria Risk in Africa
Zimmerman Lab Data
Miscellaneous
Mathematical modeling
Basic Ross-Macdonald system
Gurarie's pages
Faculty
Charles H. King
Peter A. Zimmerman
David Gurarie
Peter J. Thomas
Students
Drew P. Kouri
Peter N. Whalen
Jeana T. DaRe
John I. Heintz
RIBMS
Members of the Malaria Study Group serve as mentors and participants in Case Western Reserve University's undergraduate program in Research at the Interface of the Biological and Mathematical Sciences.
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