{"id":62,"date":"2014-07-17T12:47:36","date_gmt":"2014-07-17T12:47:36","guid":{"rendered":"http:\/\/artsci.case.edu\/skeletal\/?page_id=62"},"modified":"2021-09-13T19:04:04","modified_gmt":"2021-09-13T19:04:04","slug":"recent-publications","status":"publish","type":"page","link":"https:\/\/artsci.case.edu\/skeletal\/recent-publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

Arnold I. Caplan<\/a>\u00a0 \u00a0Diego Correa<\/a>\u00a0 \u00a0Jonathan Kenyon<\/a>\u00a0 \u00a0Donald P. Lennon<\/a>\u00a0 \u00a0Rodrigo A. Somoza<\/a>\u00a0 \u00a0J. Michael Sorrell<\/a>\u00a0 \u00a0Jean F. Welter<\/a><\/p>\n

 <\/p>\n

\"Tissue<\/a><\/a>
\nFigure from: \u201cChou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering, Part A 2013, 19(9-10):1081 – 1090.\u201d Abstract Selected as cover art for “Tissue Engineering Part A – 2013”.<\/em><\/p>\n

 <\/p>\n

<\/a>Arnold I. Caplan, Ph.D.<\/h3>\n

Lanzoni, G.; Linetsky, E.; Correa, D.; Cayetano, S.M.; Alvarez, R.A.; Kouroupis, D.; Gil, A.A.; Poggioli, R.; Ruiz, P.; Marttos, A.C.; Hirani, K.; Bell, C.A.; Kusack, H.; Rafkin, L.; Baidal, D.; Pastewski, Gawri, K.; Le\u00f1ero, C.; Mantero, A.M.A.; Metalonis, S.W.; Wang, X; Roque, L.; Masters, B.; Kenyon, N.S.; Ginzburg, E.; Xu, X.; Tan, J.; Caplan, A.I.; Glassberg, M.K.; Alejandro, R.; and Ricordi, C.: Umbilical cord mesenchymal stem cells for COVID-19 ARDS: A double blind, phase 1\/2a, randomized controlled trial. Stem Cells Trans Med. 2021;1\u201314.<\/p>\n

Kerr, B.A.; Shi, l.; Jinnah, A.H.; Harris, K.S.; Willey, J.S.; Lennon, D.P.; Caplan, A.I.; and Byzova, T.V.: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res 2021, 399(2):112456. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112456<\/p>\n

van Heeckeren, A.M.; Sutton, M.T.; Fletcher, D.R.; Hodges, C.A.; Caplan, A.I.; and Bonfield, T.L.: Enhancing cystic fibrosis immune regulation. Front Pharmacol. 2021, (12)269 DOI=10.3389\/fphar.2021.573065 https:\/\/www.frontiersin.org\/article\/10.3389\/fphar.2021.573065,<\/p>\n

Caplan, A.I.: Placebo controls: Now??? Arch Immunol Ther Exp (Warsz). Published online 29 March 2021. https:\/\/doi.org\/10.1007\/s000005-021-00612-x.<\/p>\n

Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapuram, V.; Somoza, R.A.; and Caplan, A.I.: Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021;10:1202\u20131216. DOI: 10.1002\/sctm.20-0521<\/p>\n

Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089\/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734 Abstract<\/a><\/p>\n

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002\/anie.202010648. PMID: 32835412 Abstract<\/a><\/p>\n

Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002\/anie.201910772. [Epub ahead of print] Abstract<\/a><\/p>\n

Pittenger, M.F.; Discher, D.E.; P\u00e9ault, B.M.; Phinney, D.G.; Hare, J.M.; and Caplan, A.I.: Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 4:22. doi: 10.1038\/s41536-019-0083-6. eCollection 2019. Review. PMID: 31815001 Abstract<\/a><\/p>\n

Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002\/term.2961. Abstract<\/a><\/p>\n

Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002\/anie.201910772. [Epub ahead of print] Abstract<\/a><\/p>\n

Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Li, M.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue engineering. Part A, 25(1-2):80-90, 2019. doi: 10.1089\/ten.TEA.2017.0440. Abstract<\/a><\/p>\n

Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and rat bone marrow-derived mesenchymal stem cells differ in their response to fibroblast growth factor and platelet-derived growth factor. Tissue Eng Part A. 2018 Aug 22. doi: 10.1089\/ten.TEA.2018.0126. [Epub ahead of print] Abstract<\/a><\/p>\n

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, PMID: 29999475, doi: 10.1089\/ten.TEC.2017.0513. (Epub ahead of print) Abstract<\/a><\/p>\n

Vail, D.; Somoza, R.; Caplan, A.; and Khalil, A.: Transcriptome dynamics of long non-coding RNAs and transcription factors demarcate human neonatal, adult, and MSC-derived engineered cartilage. Journal of Tissue Engineering and Regenerative Medicine (Submitted)\u00a0<\/span><\/p>\n

Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 2018, PMID: 29948374, DOI: 10.1007\/s10439-018-2067-x (Epub ahead of print)<\/p>\n

Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089\/ten.TEA.2017.0438 (Epub ahead of print)<\/p>\n

Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Chondrogenesis of mesenchymal stem cell related to both -5p and -3p miRNAs. Tissue Eng Part A. 2018 May 24. doi: 10.1089\/ten.TEA.2017.0440. [Epub ahead of print] PMID: 29676203<\/p>\n

Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002\/jor.23820 Abstract<\/a><\/p>\n

Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive\/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089\/ten.TEA.2017.0125. [Epub ahead of print]Abstract<\/a><\/p>\n

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089\/ten.tea.2016.0559Abstract<\/a><\/p>\n

Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive\/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 Aug 21. doi: 10.1089\/ten.TEA.2017.0125. [Epub ahead of print] Abstract<\/a><\/p>\n

November 2017: – new paper accepted: Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research (accepted) Abstract<\/a><\/p>\n

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089\/ten.tea.2016.0559<\/p>\n

 <\/p>\n

Diego Correa, M.D., M.Sc., Ph.D.<\/h3>\n

Correa, D.; Lin, P.; Rom, E.; Welter, J.; Duesler, L.; Yayon, A.; and Caplan. A.I.: Sequential stimulation with Fibroblast growth factors (FGFs) 2, 9 and 18 Regulate the Ultimate Phenotype of MSC-derived Chondrocytes. Osteoarthritis and Cartilage, 2014 (In press<\/em>)
\nSomoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract<\/a><\/p>\n

Lin, P.; Correa, D.; Kean, T.J.; Awadallah, A.; Dennis, J.E.; and Caplan, A.I.: Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Mol Ther. 2013 Sep 25. doi: 10.1038\/mt.2013.221. [Epub ahead of print] Abstract<\/a><\/p>\n

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem\u00a0cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract<\/a><\/p>\n

Correa, D. and Segal, S.S.: Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation. 2012 May;19(4):306-15. doi: 10.1111\/j.1549-8719.2012.00163.x. Abstract<\/a><\/p>\n

Lin P, Correa D, Lin Y, Caplan AI (2011): Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction. PLoS One, 6 (8): e23891. Abstract<\/a><\/p>\n

Caplan AI, Correa D (2011): The MSC: An Injury Drugstore. Cell Stem Cell, July 8; 9 (1): 11-15. Invited Perspective article. Abstract<\/a><\/p>\n

Caplan AI, Correa D (2011): PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs. Journal of Orthopaedic Research; Invited Perspective article (in press<\/em>) Abstract<\/a><\/p>\n

Correa D and Goldberg VM (2011): Stem Cells in Orthopaedics. American Academy of Orthopaedic Surgery (AAOS) 5(7):41-45. Invited Review article.<\/p>\n

Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia. FASEB Journal; 25(9): 3057-3067. Abstract<\/a><\/p>\n

Hesse, E.; Saito, H.; Kiviranta, R.; Correa, D.; Yamana, K.; Neff, L.; Toben. D; Duda. G.; Atfi, A.; Geoffroy, V.; Horne, W.C.; and Baron, R.: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. Journal of Cell Biology 2010, 191(7):1271-1283. Abstract<\/a><\/p>\n

Correa, D.; Hesse, E.; Seriwatanachai, D.; Kiviranta, R.; Saito, H.; Yamana, K.; Neff, L.; Atfi, A.; Coillard, L.; Sitara, D.; Maeda, Y.; Warming, S.; Jenkins, N.A.; Copeland, N.G.; Horne, W.C.; Lanske, B.; and Baron, R.: Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010, 19(4):533-546. Abstract<\/a><\/p>\n

Hesse, E.; Kiviranta, R.; Wu, M.; Saito, H.; Yamana, K.; Correa, D.; Atfi, A.; and Baron, R.: Zinc finger protein 521, a new player in bone formation. Annals of the New York Academy of Sciences 2010, 1192:32-37. Abstract<\/a><\/p>\n

 <\/p>\n

<\/a>Jonathan E. Kenyon, Ph.D.<\/span><\/h3>\n

Kenyon, J.; Fu, P.; Lingas, K.; Thomas, E.; Saurastri, A.; Santos Guasch, G.; Wald, D.; and Gerson, S.L.: Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood. 2012; 120(16):3229-36. Abstract<\/a><\/p>\n

 <\/p>\n

<\/a>Donald P. Lennon, D.D.S.<\/h3>\n

Dean, D.; George, J.E.; Varghai, D.; Cooke, M.N.; Min, K.-J.; Dennis, J.; Fisher, J.P., Rimnac, C.M.; Lennon, D.P.; Sun, J.; Mikos, A.G.; and Caplan, A.: Additive Manufacturing of Poly(Propylene Fumarate) Tissue Engineered Constructs for a Canine Critical Size Cranial Defect. Acta Biomaterialia, Submitted 2012.<\/p>\n

Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. 2014 Biofabrication 2014, 6(1):015003. doi: 10.1088\/1758-5082\/6\/1\/015003 Abstract<\/a><\/p>\n

Rowland, C.R.; Lennon, D.P.; Caplan, A.I.; and Guilak, F.: The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials. 2013 34(23):5802-12. Abstract<\/a><\/p>\n

Crapnell, K.; Blaesius, R.; Hastings, A.; Lennon, D.P.; Caplan, A.I; and Bruder, S.P.: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 2013 319(10):1409-18.Abstract<\/a><\/p>\n

Lin, P.; Lin, Y.; Lennon, D.P.; Correa, D.; Schluchter, M.; and Caplan, A.I.: Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem Cells Transl Med. 2012, 1(12):886-97. Abstract<\/a><\/p>\n

Lennon, D.P.; Schluchter, M.D.; and Caplan, A.I.: The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem Cells Transl Med. 2012 1(4):279-88. Abstract<\/a><\/p>\n

Ousema, P.H.; Moutos, F.T.; Estes, B.T.; Caplan, A.I.; Lennon, D.P.; Guilak, F,; and Weinberg, J.B.: The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials. 2012 33(35):8967-74. Abstract<\/a><\/p>\n

Bai, L.; Lennon, D.P.; Caplan, A.I.; DeChant, A.; Hecker, J.; Kranso, J.; Zaremba, A.; and Miller, R.H.: Hepatocyte growth factor mediates mesenchymal stem cell\u2013induced recovery in multiple sclerosis models. Nat Neurosci. 2012 15(6):862-70. Abstract<\/a><\/p>\n

Bonfield, T.L.; Nolan Koloze, M.T.; Lennon, D.P.; and Caplan, A.I.: Defining human mesenchymal stem cell efficacy in vivo<\/em>. J Inflamm (Lond). 2010, 25;7:51. Abstract<\/a><\/p>\n

Bonfield, T.L.; Koloze, M.; Lennon, D.; Zuchowski, B.; Yang, S.E.; and Caplan,A.I.: Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am J Physiol Lung Cell Mol Physiol, 2010 Dec;299(6):L760-70. Abstract<\/a><\/p>\n

Miller, R.H.; Bai, L.; Lennon, D.P.; and Caplan, A.I.: The potential of mesenchymal stem cells for neural repair. Discov Med. 2010, 9(46):236-42. Abstract<\/a><\/p>\n

<\/a>Rodrigo A. Somoza, Ph.D.<\/span><\/h3>\n

November 2017: – new paper accepted: Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research (accepted) Abstract<\/a><\/p>\n

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089\/ten.tea.2016.0559<\/p>\n

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. Journal of Experimental medicine, (2014) (submitted<\/em>).<\/p>\n

Somoza, R.A; Acevedo, C.A.; Weinstein-Oppenheimer, C.; Luz, P.A.; Carri\u00f3n, F.; and Young, M.E.: TGF-\u00df3 secretion by human dental follicle mesenchymal stem cells (hDF-MSC) encapsulated in alginate and fibrin scaffolds. Journal of Tissue Engineering and Regenerative Medicine 2014 (in revision<\/em>).<\/p>\n

Correa, D.; Somoza, R.A.; Lin, P.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan. A.I.: Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. Osteoarthritis and Cartilage, 2014 pii: S1063-4584(14)01336-3. Abstract<\/a><\/p>\n

Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of mesenchymal stem cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 (Epub ahead of print) Abstract<\/a><\/p>\n

Acevedo, C.A.; Somoza, R.A.; Weinstein-Oppenheimer, C.; Silva, A.; Moreno, M.; Sanchez, E.; Albornoz, F.; Young, M.E.; MacNaughtan, W.; and Enrione, J. Improvement of human skin cells growth by radiation induced modifications of a Ge\/Ch\/Ha-scaffold. Bioprocess Biosyst Eng 2013 36:317\u2013324. Abstract<\/a><\/p>\n

Somoza, R.A. and Rubio, F.J: Cell therapy using induced pluripotent stem cells or somatic stem cells: this is the question. Current Stem Cell Research and Therapy. 2012 7(3):191-196. Abstract<\/a><\/p>\n

Somoza, R.; Conget, P.; and Rubio, F.J.: Neuropotency of human mesenchymal stem cell cultures: Clonal studies reveal the contribution of cell plasticity and cell contamination. Biology of Blood and Marrow Transplantation 2012 14:546-555. Abstract<\/a><\/p>\n

Acevedo, C.; Somoza, R.; Weinstein-Oppenheimer, C.; Brown, D.; and Young, M.: Growth factor production from fibrin-encapsulated human keratinocytes. Biotechnology Letters 2010 32:1011\u20131017. Abstract<\/a><\/p>\n

Somoza, R.; Juri, C.; Baes, M; Wyneken, U.; and Rubio, F.J.: Intranigral transplantation of epigenetically-induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson\u00b4s disease. Biology of Blood and Marrow Transplantation 2010 16:1530-1540. Abstract<\/a><\/p>\n

Enrione, J.; Osorio, F.; L\u00f3pez, D.; Weinstein-Oppenheimer, C.; Fuentes, M.A.; Cereani, R.; Brown, D.I.; Albornoz, F.; S\u00e1nchez, E.; Villalobos, P.; Somoza, R.A.; Young, M.E.; and Acevedo, C.A.: Characterization of a gelatin\/chitosan\/hyaluronan scaffold-polymer. Electronic Journal of Biotechnology, 2010 DOI: 10.2225\/vol13-issue5-fulltext-15.<\/p>\n

 <\/p>\n

<\/a>J. Michael Sorrell, Ph.D.<\/h3>\n

Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research (accepted) Abstract<\/a><\/p>\n

Caplan, A.I. and Sorrell, J.M.: The MSC curtain that stops the immune system. Immunol Lett. 2015 pii: S0165-2478(15)00103-0. doi: 10.1016\/j.imlet.2015.06.005. [Epub ahead of print] Abstract<\/a><\/p>\n

Sorrell, J.M.; Baber, M.A.; Traktuev, D.O.; March, K.L.; and Caplan, A.I.: The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials. 2011 32(36):9667-76. Abstract<\/a><\/p>\n

Carrino, D.A.; Calabro, A.; Darr, A.B.; Dours-Zimmermann, M.T.; Sandy, J.D.; Zimmermann, D.R.; Sorrell, J.M.; Hascall, V.C.; and Caplan, A.I.: Age-related differences in human skin proteoglycans. Glycobiology. 2011, 21(2):257-68. Abstract<\/a><\/p>\n

Sorrell, J.M. and Caplan, A.I.: Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010, 24;1(4):30. Abstract<\/a><\/p>\n

 <\/p>\n

<\/a>Jean F. Welter, M.D., M.Sc., Ph.D.<\/h3>\n

Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089\/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734 Abstract<\/a><\/p>\n

Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007\/978-1-0716-1119-7_1. PMID: 33315191 Abstract<\/a><\/p>\n

Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016\/j.jmbbm.2020.103923. PMID: 32952604 Abstract<\/a><\/p>\n

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002\/anie.202010648. PMID: 32835412 Abstract<\/a><\/p>\n

Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419\u2013427. Abstract<\/a><\/p>\n

Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002\/anie.201910772. [Epub ahead of print] Abstract<\/a><\/p>\n

Larson, B.L.; Yu, S.N.; Park, H.; Estes, B.T.; Moutos, F.T.; Bloomquist, C.J.; Wu, P.B.; Welter, J.F.; Langer, R.; Guilak, F.; and Freed, L.E.: Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds. Journal of Tissue Engineering and Regenerative Medicine. 2019 doi: 10.1002\/anie.2019107722019 Abstract<\/a><\/p>\n

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 24(8):443-456, 2018, PMID: 29999475, doi: 10.1089\/ten.TEC.2017.0513. Abstract<\/a><\/p>\n

Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, DOI: 10.1007\/s10439-018-2067-x<\/p>\n

Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089\/ten.TEA.2017.0438 (Epub ahead of print)<\/p
\nVerbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)<\/p>\n

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)<\/p>\n

Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016\/j.actbio.2017.07.016. [Epub ahead of print] Abstract<\/a><\/p>\n

Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)<\/p>\n

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)<\/p>\n

Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016\/j.actbio.2017.07.016. [Epub ahead of print] Abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Arnold I. Caplan<\/a>\u00a0 \u00a0Diego Correa<\/a>\u00a0 \u00a0Jonathan Kenyon<\/a>\u00a0 \u00a0Donald P. Lennon<\/a>\u00a0 \u00a0Rodrigo A. Somoza<\/a>\u00a0 \u00a0J. Michael Sorrell<\/a>\u00a0 \u00a0Jean F. Welter<\/a><\/p>\n

 <\/p>\n

<\/a><\/a>
\nFigure from: \u201cChou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering, Part A 2013, 19(9-10):1081 – 1090.\u201d Abstract Selected as cover art for “Tissue Engineering Part A – 2013”.<\/em><\/p>\n

 
\n<\/a>Arnold I.<\/p>\n

Continue reading… Recent Publications<\/span><\/a><\/p>\n","protected":false},"author":19,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"spay_email":""},"_links":{"self":[{"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/pages\/62"}],"collection":[{"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/comments?post=62"}],"version-history":[{"count":12,"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/pages\/62\/revisions"}],"predecessor-version":[{"id":537,"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/pages\/62\/revisions\/537"}],"wp:attachment":[{"href":"https:\/\/artsci.case.edu\/skeletal\/wp-json\/wp\/v2\/media?parent=62"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}