Skeletal Research Center

Home / Curriculum Vitae / Jean Frederic Welter, M.D., M.Sc., Ph.D.

Jean Frederic Welter, M.D., M.Sc., Ph.D.

Research Associate Professor
Skeletal Research Center, Department of Biology,
Case Western Reserve University
Millis Science Center, Room 112A
2080 Adelbert Road
Cleveland, Ohio 44106-7080
Tel.: (216) 368-1333 (Office), (216) 368-2777 (Lab),
Fax: (216) 368-4077
E-mail: jfw2@cwru.edu

May, 2014

Educational Background:

1996 Ph.D. (Physiology & Biophysics), Case Western Reserve University, Cleveland, OH, U.S.A.
1990 M.Sc. (Experimental Surgery), Dean’s Honors List McGill University, Montréal, Québec, Canada
1984 Permanent ECFMG certificate, Foreign Medical Graduate Examination in the Medical Sciences (F.M.G.E.M.S.)
1984 Doktor der gesamten Heilkunde (M.D.), School of Medicine, Leopold Franzens Universität, Innsbruck, Austria

 

Professional Experience:

2007 – Research Associate Professor, Department of Biology Case Western Reserve University, Cleveland, OH
2012 – Associate Professor, Center for Regenerative Medicine, School of Medicine, Division of General Medical Sciences, Case Western Reserve University, Cleveland, OH (Secondary Appointment)
2004 – 2007 Senior Research Associate, Skeletal Research Center Case Western Reserve University, Cleveland, OH
1998 – 2004 Assistant Professor, Department of Orthopædics, Case Western Reserve University, Cleveland, OH
1996 – 1998 Instructor, Department of Orthopædics, Case Western Reserve University, Cleveland, OH
1990 – 1996 Ph.D. Candidate, Department of Physiology & Biophysics, Case Western Reserve University, Cleveland, OH
1989 – 1990 Post-Doctoral Fellow, Department of Orthopædics, Case Western Reserve University, Cleveland, OH
1988 – 1989 PGY-1 Surgery Resident, Surgery Residency Program, Case Western Reserve University, Cleveland, OH
1985 – 1988 Research Fellow, Montreal Children’s Hospital Research Institute (Orthopædic Research Laboratory), Montréal, PQ, Canada

 

Professional Affiliations:

2010 – Present Tissue Engineering and Regenerative Medicine International Society
2008 – Present Osteoarthritis Research Society International
2007 – Present Biomedical Engineering Society
2003 – Present International Cartilage Repair Society
2001 – Present American Society for Bone and Mineral Research
1998 – Present American Society for Biochemistry & Molecular Biology
1997 – Present Orthopædic Research Society
1989 – Present American Association for the Advancement of Science

 

Honors and Awards:

2006 ICRS poster award “Cum Laude
2003, 2005 Arthritis Foundation travel ward
1991 – 1993 Research Fellowship, Cell Physiology Training Program. Department of Physiology & Biophysics, Case Western Reserve University, Cleveland, OH
1990 McGill University, Dean’s Honors List
1989 – 1990 Research Fellowship, NIH Training Program in Musculoskeletal Research. Department of Orthopædics, Case Western Reserve University, Cleveland, OH
1985 – 1988 Fellow of the McGill University – Montreal Children’s Hospital Research Institute

 

Teaching Experience:

2013 Joe Heebner, ENGAGE fellowship sponsor
2013 Marine Gu, M.Sc. co-advisor and committee member
2013 Jake Althans, Gilmour Academy student co-advisor
2012 Sarah Abdalian, Gilmour Academy student co-advisor
2011 Marine Gu, undergraduate senior project co-advisor
2011 Eduardo Arellano, summer laboratory project co-advisor
2010 – 2011 Marcin Citak, undergraduate senior project co-advisor
2009 Jason Walker, summer undergraduate student
2009 – present Thesis committee for Shiv Shanmugan, Vinay Sethia, Pavan Sethia, Balambal Subramanian, Hong Wang, and JT Tan: MS in Entrepreneurial Biotechnology Program.
2008 – 2009 Ashley McKee, undergraduate senior project co-advisor
2008 Michael Pelyak, ENGAGE fellowship sponsor
2006 – 2012 EBME 325, Introduction to Tissue Engineering, guest lecturer. Department of Biomedical Engineering, CWRU
2005 – 2006 Ross Anderson, undergraduate senior project co-advisor
2005 – 2008 Bioreactors for MSC differentiation; “Cell-Based Therapies and Tissue Engineering” (CTTE) short course
2003 – 2004 Mukund Deglurkar, M.B.B.S., M.S., F.R.C.S. Research Fellow, MD candidate, University of Wales
2003 – 2004 Reid Wenger, D.D.S., Research Fellow
2002 Rabia Ahmed, summer undergraduate student.
1997 – 1998 Shmuel Tsurel, M.D.; Research Fellow
1991 – 1994 Introduction to Microcomputers. Department of Physiology & Biophysics, CWRU

 

Funded Research:

  • AFIRM II 2014 – 2017 subproject co-investigator.
  • Intra-articular delivery of injectable sustained-release microsphere drug formulations. CSCRM/BRCP: 7/1/09 – 6/30/2012. Principal Investigator
  • Tissue engineered cartilage repair. (PI: Arnold Caplan) NIH/NIAMS-NIBIB P01 AR053622 7/01/08 – 06/30/10 Core director and sub-project Co-principal investigator
  • Mechanisms of chondroprotection by pomegranate fruit extract R01 AT003627-01A1 PI: Tariq Haqq i7/1/2007 – 6/30/2012 Co-investigator.
  • Engineering cartilage: an integrated approach to biological joint repair. NIH R01 AR050802. 4/5/2005 – 3/31/2010. Principal investigator.
  • Chondrogenic preconditioning of cell/scaffold constructs for the repair of large cartilage defects. Arthritis Foundation Biomedical Research Grant. 07/01/2002 – 06/30/2005. Principal investigator.
  • Clinical tissue engineering center (CTEC), BRTT, PI: George Muschler, 04/01/2005 – 03/31/2008 Co-investigator.
  • Tissue-engineered skin with built-in capillary flow networks. NIH R01 EB006203. PI: Harihara Baskaran, 03/01/2006 – 02/28/2010, Co-investigator.
  • Tissue engineering of cartilage subtypes. NIH R01 DE015322. PI: James Dennis, 08/01/2004 – 7/31/2008, Co-investigator.
  • Strength and resorption of biodegradable skull implants. NIH R01-DE13740. PI: David Dean, Co-investigator. Start date pending. Co-investigator.
  • Effects of processing techniques for tantalum trabecular bone implant surfaces. Zimmer, Inc. PI: Victor Goldberg, 07/01/2003 – 06/30/2005, Co-investigator.
  • State-of-the-Art pH Monitoring in Bioreactors. NSF STTR Phase I. PI: John Robecheck, 07/01/03 – 06/30/04, Co-investigator.
  • Tissue engineered implants for cartilage regeneration. Ohio Board of Regents/Case Western Reserve University Presidential Research Initiative. 01/01/2001 – 12/31/2002. Principal investigator
  • Gene transcription in mechanically loaded bone cells. NIH R03 AR 45777. 10/1/1998 – 9/30/2001. Principal investigator

Pending/Planned Proposals:

  • IRT/Procaps: Pre-clinical Cytogel-MSC 2014 – 2015 Principal investigator. (awarded, pending contract negotiations)
  • NIH/NIBIB P41-EB017186, CWRU center for multi-modal evaluation of engineered cartilage (Caplan, PI), Project Co-director.
  • NIH/NIAMS R21 Imaging Chondrogenic Differentiation of MSC using microRNA (Lee, PI), Co-principal investigator.
  • CDMRP PRORP program Osteochondral Scaffold Concept for Repair of Large Postraumatic Arthritic Defects (Akkus, PI), Co-investigator.
  • CDRMP Sequential exposure to growth factors as a novel strategy to produce durable stem cell-derived cartilage tissue for the treatment of post traumatic osteoarthritis. (Bukulmez, PI), Co-investigator
  • CDRMP Lupus proposal (Jones, PI), Co-investigator
  • SBIR – Improved cartilage regeneration using concentrated bone marrow and a novel chondroitin sulfate-collagen based scaffold, (subaward).
  • NIH/NIAMS R01 AR064795: A hypothesis for the mechanism of viscosupplementation, Principal Investigator.
  • OTF: OHIO-alive. Pilot project. Principal investigator.

Ongoing Collaborations:

At Case Western Reserve University:

  • Davood Varghai: Cranial explant organ culture
  • David Prologo: Intradisc MSC injections
  • Harihara Baskaran: Mass transport studies in tissue-engineered cartilage and skin. Metabolic engineering of anaerobic bacteria.
  • Charles Malemud: Apoptosis in OA.
  • Victor Goldberg: Porous ingrowth bone implants, bone grafts and bone graft substitutes.
  • David Dean: Tissue engineering of cranial implants.
  • Tariq Haqqi: Oxidative stress and MSC performance.
  • C.C. Liu: Glucose consumption by differentiating mesenchymal stem cells

Off Campus:

  • Tracey Richey/Mark Smith (Oakwood Labs): Sustained-release intra-articular drug delivery
  • H. Michael Cheung (University of Akron): Dynamic light scattering in molecular crowding.
  • Lisa Freed (Massachusetts Institute of Technology): Cartilage tissue engineering.
  • John Robecheck, (Sensirox, Inc), Jay Johnson (UDRI): Development of micro-pH sensors.
  • R. Tracy Ballock, (Cleveland Clinic Foundation): Investigation of Heuter-Volkmann effect in vitro using a hydrostatic bioreactor.
  • Dwayne Bisgrove, Ph.D., System Biosciences (SBI): Lentiviral reporter/selection vectors to report cell differentiation.

Service to Professional Community:

  • 2013 Ad hoc member, NIH Cell Culture Bioreactor Study Section ZRG1 IDM-M (30)
  • 2013 Reviewer NMRC (Singapore) Clinician Scientist Awards
  • 2012 – 2014 International Expert Panel member. National Medical Research Council (Singapore)
  • 2012 Member, NIH COBRE renewal review panel
  • 2011 Study section member for Arthritis Research UK
  • 2010, 2011 Reviewer, NCRM pilot grant proposals
  • 2009 Moderator, Progenitors and Stem Cells session, Orthopaedic Research Society meeting, Las Vegas, NV
  • 2009 Member, NIH Challenge Grant Review Panel #10, ZRG1 BDA-A (58) R
  • 2008, 2011 Member, Arthritis Research Campaign (U.K.) study section
  • 2008 Member, Special Emphasis Panel/Scientific Review Group 2009/01 MTE
  • 2008 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-H (M1) 1
  • 2006, 2007 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-J (M1) (1)
  • 2005 Ad hoc member, NIH Special Emphasis Panel/Scientific Review Group ZAR1 EHB-G (O1) (1)
  • 2005 Judge, MTEC-2005 presentation awards
  • 2004, 2006-2012 Ad hoc reviewer for the National Medical Research Council (Singapore) study section
  • 2004, 2006, 2007 Judge, graduate student poster competition at Research ShowCASE
  • 2003 Organizing committee for the 5th Bone Fluid Flow Workshop, Cleveland, OH. September 17 – 18
  • 2002 – 2003 Ad hoc member, NIH biomedical engineering study section ZRG1 SSS-M 58
  • 2001 – 2004 Member, Department of Orthopædics Research Committee
  • Ad hoc reviewer for Acta Biomaterialia
  • Ad hoc reviewer for Arthritis Research and Therapy
  • Ad hoc reviewer for Biomaterials
  • Ad hoc reviewer for BioTechniques
  • Ad hoc reviewer for Bone
  • Ad hoc reviewer for British Journal of Cancer
  • Ad hoc reviewer for Cells, Tissues, Organs
  • Ad hoc reviewer for Current Eye Research
  • Ad hoc reviewer for Genomics
  • Ad hoc reviewer for the Journal of Biological Chemistry
  • Ad hoc reviewer for the Journal of Biomedical Materials Research
  • Ad hoc reviewer for the Journal of Investigative Dermatology
  • Ad hoc reviewer for the Journal of Orthopædic Research
  • Ad hoc reviewer for the Orthopædic Research Society
  • Ad hoc reviewer for Tissue Engineering
  • Ad hoc reviewer for Yonsei Medical Journal

Patents:

  • Holt, V.; Welter, J.F.; Berilla, J.A.; Harris, M.; and Caplan, A.I.: Cell capture apparatus and staining device. Provisional patent application number 61/875918 filed September 10, 2013.
  • Welter, J.F.; Solchaga, L.A.; Berilla, J.A.; and Penick, K.: Apparatus and method for tissue engineering. US Patent # 8,507,266 issued August 13, 2013.

Publications:

Manuscripts Submitted/in Preparation:

  1. Larson, B.L.; Yu, S.N.; Park, H.; Estes, B.T.; Moutos, F.T.; Wu, P.B.; Guilak, F.; Welter, J.F.; Langer, R.; and Freed, L.E.: Chondrogenic and Osteogenic Plasticity of Human Mesenchymal Stem Cells. Cell Stem Cells 2014 (submitted)
  2. Correa, D.; Somoza, R.; Lin, P.; Greenberg, S.; Rom, E.; Duesler, L.; Welter, J.F.; Yayon, A.; and Caplan, A.I.: Sequential stimulation with fibroblast growth factors (FGF) 2, 9 and 18, modulate the fate of MSC-derived chondrocytes optimizing them for cartilage repair. Osteoarthritis & Cartilage 2014 (in revision)
  3. Mansour, J.M.; Gu, D.W.; Chung, C.-Y.; Heebner, J.; Schluchter, M.D.; and Welter, J.F.: Towards Ultrasound elastography. Annals of Biomedical Engineering 2014 (in revision)
  4. Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014, (Submitted)
  5. Solchaga, L.A.; Penick, J.; Goldberg, V.M.; Caplan, A.I; and Welter, J.F.: TGF-β1 and dexamethasone regulate hypertrophy during chondrogenic differentation of bone marrow-derived mesenchymal stem cells (in preparation)
  6. Berilla, J.; Solchaga, L.A.; Baskaran, H.; and Welter, J.F.: Design of a cartilage tissue engineering bioreactor (submitted)
  7. Liang, W.H.; Janakiraman, V.; Welter, J.F.; and Baskaran, H.: Composite tissue engineered skin constructs made of collagen dermal analogs and cultured keratinocyte epidermal analogs (in preparation)
  8. Berilla, J. and Welter, J.F.: Image analysis algorithm for measuring local thickness (in revision)
  9. Welter, J.F.; Baskaran, H.; Berilla, J.A.; Caplan, A.I; Goldberg, V.M.; Penick, K.; and Solchaga, L.A.: Transient aggregate culture enables human mesenchymal stem cell-based cartilage tissue engineering (in preparation)
  10. Welter, J.F.: Simplified color thresholding of histological images using color-space rotation. (in preparation)
  11. Welter, J.F. and Mansour, J.M.: Evaluation of tissue engineered cartilage (in preparation)

Peer-Reviewed Manuscripts:

  1. Somoza, R.; Welter, J.; Correa, D.; and Caplan, A.: Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges. Tissue Engineering part B, April 22, 2014 [epub ahead of print] Abstract
  2. Wallace, J.; Wang, M.O.; Thompson, P.; Busso, M.; Belle, V.; Mammoser, N.; Kim, K.; Fisher, J.P.; Siblani, A.; Xua, Y.; Welter, J.F.; Lennon, D.P.; Sun, J.; Mikos, A.G.; Caplan, A.I.; Dean, D.: Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication 2014 Jan 15;6(1) Abstract
  3. Welter, J.F.; Penick, J.; Solchaga, L.A.: Assessing adipogenic potential of mesenchymal stem cells: a rapid three-dimensional culture screening technique. Stem Cells International, 2013, Article ID 806525 Abstract
  4. Chou, C.-L.; Rivera, A.L.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue Engineering, Part A 2013, 19(9-10):1081 – 1090. Abstract
  5. Mansour, J.M. and Welter, J.F.: Multimodal evaluation of tissue-engineered cartilage. Journal of Medical and Biological Engineering 2013, 33(1):1-16 Abstract
  6. Shao, Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia modulate ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50(1):79 – 84 Abstract
  7. Walker, J.M.; Myers, A.M.; Schluchter, M.D.; Goldberg, V.M.; Caplan, A.I.; Berilla, J.A.; Mansour, J.M.; and Welter, J.F.: Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound. Annals of Biomedical Engineering 2011, 39(10):2521 – 2530Abstract
  8. Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach for development of microfabrication-based cancer migration assay. Annals of Biomedical Engineering 2011, 39(9):2346 – 2359. Abstract
  9. Auletta, J.J.; Zale, E.A.; Welter, J.; and Solchaga, L.: Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells International 2011, Article ID 235176:1 – 10. Abstract
  10. Abrahamsson, C.A.; Yang, F.; Park, H.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I.; Brunger, J.; Guilak, F.; Freed, L.E.: Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds. Tissue Engineering, Part A 2010, 16(12):3709 – 3718). Abstract
  11. Liang, W.H.; Kienitz, B.L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Optimizing collagen-GAG scaffolds for tissue engineering applications using centrifugation. Journal of Biomedical Materials Research, Part A 2010, 94(4):1050 – 1060.Abstract
  12. Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(ε-caprolactone) scaffolds. Biomaterials 2010, 31(8):2193 – 2200. Abstract
  13. Solchaga, L.A.; Penick, J.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone marrow-derived mesenchymal stem cells. Tissue Engineering 2009, (e-Pub ahead of print). Abstract
  14. Welter, J.F.; Solchaga, L.A.; and Penick, K.J.: Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay. BioTechniques 2007, 42(6):732 – 737. Abstract
  15. Henderson, J.H.; Welter, J.F.; Mansour, J.M.; Niyibizi, C.; Caplan, A.I; and Dennis, J.E.: Cartilage tissue engineering for pediatric laryngotracheal reconstruction: Comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Engineering 2007, 13(4):843 – 853. Abstract
  16. Deglurkar, M.; Davy, D.T.; Goldberg, V.M.; Stewart, M.C.; and Welter, J.F.: Evaluation of machining methods for porous tantalum implants in a rabbit intramedullary osseointegration model. Journal of Biomedical Materials Research (B) 2007, 80B(2):528 – 540. Abstract
  17. Henderson, J.H.; Mansour, J.M.; Welter, J.F.; Awadallah, A.; Ginley, N.; Caplan, A.I.; and Dennis, J.E.: Cartilage tissue engineering: comparison of chondrocytes from three anatomic locations in the rabbit. CWRU Orthopaedic Journal 2006, 3(1):33- 42.
  18. Solchaga, L.A.; Tognana, E.; Penick, K.; Baskaran, H.; Caplan, A.I.; Goldberg, V.G.; and Welter, J.F.: A rapid vacuum-seeding technique for the assembly of large tissue-engineered cell/scaffold composites. Tissue Engineering 2006, 12(7):1851 – 1863. Abstract
  19. Wenger, R.; Hans, M.G.; Welter, J.F.; Solchaga, L.A.; Sheu, Y.R.; and Malemud, C.J.: Tissue-engineered human cartilage-constructs from human osteoarthritic chondrocytes. Frontiers in Biosciences, 2006, 11:1690 – 1695. Abstract
  20. Penick, K.J.; Solchaga, L.A.; and Welter, J.F.: A high-throughput aggregate culture system to assess the chondrogenic potential of mesenchymal stem cells. BioTechniques 2005, 39(5):687 – 691. Abstract
  21. Penick, K.; Berilla, J.; Solchaga, L.A.; and Welter, J.F.: Performance of polyoxymethylene plastic (POM) as a component of a tissue engineering bioreactor. Journal of Biomedical Materials Research 2005, 75(1):168 – 174. Abstract
  22. Solchaga, L.A.; Penick, K.; Porter, J.; Caplan, A.I.; Goldberg, V.M.; and Welter, J.F.: FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J. Cellular Physiology 2005, 203:398 – 409. Abstract
  23. Solchaga, L.A.; Penick, K.; and Welter, J.F.: A manual mosaicking approach to generating large, high resolution digital images of histological sections. Proceedings of the Royal Microscopical Society 2004, 39(4):313 – 320.
  24. Stewart, M.C.; Welter, J.F.; and Goldberg, V.G.: Effect of Hydroxyapatite/Tricalcium-Phosphate coating on osseointegration of plasma-sprayed titanium alloy implants. Journal of Biomedical Materials Research 2004, 69A(1):1 – 10. Abstract
  25. Jabbour, L.; Welter, J.F.; Kollar, J.; and Hering, T.M.: Sequence, gene structure, and expression pattern of CNTL, a minor class intron-containing gene: evidence for a role in apoptosis. Genomics 2003, 81(3):292 – 303. Abstract
  26. Islam, N.; Haqqi, T.M.; Jepsen, K.J.; Kraay, M.; Welter, J.F.; Goldberg, V.M.; and Malemud, C.J.: Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, c-myc, p53 and bax-α, and suppression of bcl-2. Journal of Cellular Biochemistry 2002, 87: 266 – 278. Abstract
  27. Balasubramanian, S.; Agarwal, C.; Efimova, T.; Dubyak, G.R.; Banks, E.; Welter, J.; and Eckert, R.L.: Thapsigargin suppresses phorbol ester-dependent human involucrin promoter activity by suppressing CCAAT-enhancer-binding protein alpha (C/EBPα) DNA binding. Biochemical Journal 2000, 350(Pt 3):791 – 796. Abstract
  28. Agarwal, C.; Effimova, T.; Welter, J.F.; Crish, J.F.; and Eckert, R.L.: CCAAT/Enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester. Journal of Biological Chemistry 1999, 274(10):6190 – 6194. Abstract
  29. Effimova, T.; LaCelle, P.; Welter, J.F.; and Eckert, R.L.: Regulation of human involucrin promoter activity by a protein kinase C, RAS, MEKK1, MEK3, P38/RK, AP-1 signal transduction pathway. Journal of Biological Chemistry 1998, 273(38):24387 – 24395. Abstract
  30. Banks, E.B.; Crish, J.F.; Welter, J.F.; and Eckert, R.L.: Characterization of human involucrin promoter distal regulatory region transcriptional activator elements – a role for SP1 and AP-1 binding sites. Biochemical Journal 1998, 331(Pt.1):61 – 69. Abstract
  31. Robinson, N.A.; Lapic, S.; Welter, J.F.; and Eckert, R.L.: S100A11, S100A10, annexin I, desmosomal proteins, SPRs, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. Journal of Biological Chemistry 1997, 272(18):12035 – 12046. Abstract
  32. Eckert R.L.; Crish J.F.; Banks E.B.; Welter, J.F.: The epidermis: genes on – genes off. Journal of Investigative Dermatology 1997, 109(4): 501 – 509. Abstract
  33. Eckert, R.L. and Welter, J.F.: Keratinocyte differentiation: genes and their regulation. Cell Death and Differentiation 1996, 3:373 – 383. Abstract
  34. Eckert, R.L. and Welter, J.F.: Transcription factor regulation of epidermal keratinocyte gene expression. Molecular Biology Reports 1996, 23:59 – 70. Abstract
  35. Welter, J.F.; Gali, H.U.; Crish, J.F.; and Eckert, R.L.: Regulation of human involucrin promoter activity by POU domain proteins. Journal of Biological Chemistry 1996, 271(25):14727 – 14733. Abstract
  36. Welter, J.F.; Crish, J.F.; Agarwal, C.; and Eckert, R.L.: Additions and corrections to: Fos related antigen (Fra-1), junB and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. Journal of Biological Chemistry 1996, 271(18):11034. PMID: 8662708
  37. Welter, J.F. and Eckert, R.L.: Differential expression of the fos and jun family members c-fos, fosB, fra-1, fra-2, c-jun, junB and junD during human epidermal differentiation. Oncogene 1995, 11(12):2681 – 2687. Abstract
  38. Welter, J.F.; Crish, J.F.; Agarwal, C.; and Eckert, R.L.: Fos related antigen (fra-1), junB and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. Journal of Biological Chemistry 1995, 270(21):12614 – 12622. Abstract
  39. Eckert, R.L.; Yaffe, M.B.; Crish, J.F.; Murthy, S.; Rorke, E.A.; and Welter, J.F.: Involucrin – Structure and role in envelope assembly. Journal of Investigative Dermatology 1993, 100(5):613 – 617. Abstract
  40. Welter, J.F.; Shaffer, J.W.; Stevenson, S.; Davy, D.T.; Field, G.A.; Klein L.; Li, X.Q.; Zika, J.M.; and Goldberg, V.M.: Cyclosporin A and tissue antigen matching in bone transplantation. Fibular allografts studied in the dog. Acta Orthopædica Scandinavica 1990, 61(6):517 – 527. Abstract

Book Chapters:

  1. Lee, Z.; Dennis, J.; Welter, J.; and Caplan, A.: Imaging stem cell differentiation for cell-based tissue repair. In: Methods in Enzymology: Imaging and Spectroscopy in Living Cells, Elsevier Publishing 2012 506:247-63. PMID: 22341228
  2. Welter, J.F.; Solchaga, L.A.; and Baskaran, H.: Chondrogenesis from human mesenchymal stem cells: Role of culture conditions. In: Hayat, E., ed.: Stem cells and cancer stem cells: Therapeutic applications in disease and injury, volume 5. Springer 2012:269 – 281 ISBN: 978-94-007-2899-8
  3. Solchaga, L.A.; Penick, K.J.; and Welter, J.F.: Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips & tricks. In: Vemuri, M.C.; Rao, M.S.; and Chase, L.G., eds.: Mesenchymal Stem Cell Assays and Applications. Humana Press, 2011, 698:253 – 278. Abstract
  4. Goldberg, V.M. and Welter, J.F.: Autografts. In: Callaghan, J.J.; Rosenberg, A.G.; and Rubash, H.E., eds.: The adult hip, Lippincott-Raven. 2006(23):304 – 328.
  5. Welter, J.F. and Goldberg, V.M.: Bone grafting and substitutes. In: Orthopædic knowledge update. AAOS, 2005:241 – 248.
  6. Solchaga, L.A.; Welter, J.F.; and Caplan, A.I.: Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype. In: Sabatini, M.; De Ceuninck, F.; and Pastoureau, P., eds.: Cartilage and osteoarthritis (Methods in Molecular Medicine series). Humana Press, 2004:53 – 68. Abstract
  7. Welter, J.F.; Solchaga, L.A.; and Stewart, M.C.: High efficiency non-viral transfection of chondrocytes. In: Sabatini, M.; De Ceuninck, F.; and Pastoureau, P., eds.: Cartilage and osteoarthritis (Methods in Molecular Medicine series). Humana Press, 2004:129 – 146. Abstract
  8. Solchaga, L.A.; Welter, J.F.; Caplan, A.I; and Goldberg, V.M.: Cartilage Tissue Engineering. In: Callaghan, J.J.; Rosenberg, A.G.; Rubash, H.E.; Simonian, P.T.; and Wickiewicz, T.L., eds.: The adult knee. Lippincott, Williams & Wilkins, Publishers, 2003:251 – 258.

Abstracts:

  1. Prologo, J.D.; Duesler, L.; Berilla, J.; Baskaran, H.; Schluchter, M.; Corn, D; and Welter, J.: Effects of pressure and shear related to the needle delivery of stem cells. Society of Interventional Radiology 2013 (submitted)
  2. Heebner, J.; Chung, C.-Y.; Gu, M.; Welter, J.F.; and Mansour, J.M.: Prediction of storage, Young’s and aggregate moduli of agarose hydrogels as surrogates for tissue-engineered cartilage from ultrasonic measurement. NCRM retreat Cleveland, OH, December 2, 2013
  3. Prologo, J.D.; Duesler, L.; Berilla, J.; Baskaran, H.; Schluchter, M.; and Welter, J.: Effects of pressure and shear related to the needle delivery of stem cells. NCRM retreat Cleveland, OH, December 2, 2013
  4. Verbus, E.; Yuan, L.; Merry, C.; Khalil, A. Welter, J.; Caplan, A.; and Lee, Z.: Imaging chondrogenic differentiation with micro RNA. NCRM retreat Cleveland, OH, December 2, 2013
  5. Chung, C.-Y.; Heebner, J.E.; Duesler, L.D.; Mansour, J.M.; and Welter, J.F.: The feasibility of using ultrasound elastography to determine material properties of engineered cartilage in a sterile bioreactor. MSC2013, Cleveland, OH, August 19-21, 2013
  6. Heebner, J.; Chung, C.-Y.; Gu, M.; Welter, J.F.; and Mansour, J.M.: Prediction of storage, Young’s and aggregate moduli of agarose hydrogels as surrogates for tissue-engineered cartilage from ultrasonic measurement of speed of sound. MSC2013, Cleveland, OH, August 19-21, 2013
  7. Rivera, A.L.; Mulcahy, B.; Chou, C.-L.; Sakai, T.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: 3-Dimensional Osteochondral Tissue Engineering AIChE 2013, San Francisco, CA, November 3-8, 2013: 337618
  8. Chou, C.-L.; Rivera, A.L.; Sakai, T.; Drazba, J.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: A multiscale approach to stem cell-based chondrogenesis for cartilage repair AIChE 2013, San Francisco, CA, November 3-8, 2013: 348582
  9. Wang, K.-C.; Welter, J.; Egelhoff, T.; Duesler, L.; and Baskaran, H.: Myosin-II modulates the differentiation of human mesenchymal stem cells toward a myogenic versus chondrogenic fate. Proceedings of the 2013 Research ShowCASE, Case Western Reserve University, Cleveland, OH. April 12, 2013
  10. Mott, E.; Belle, V.; Welter, J.; Lennon, D.; Duesler, L.; Wang, M.; Busso, M.; Wallace, J.; Bensusan, J.; Fisher, J.; Dean, D.; and Caplan, A.: Additive manufacturing of poly (propylene fumarate) scaffolds and bioreactor pre-culturing of canine mesenchymal stem cells for cranial tissue engineering. Proceedings of the 2013 Research ShowCASE, Case Western Reserve University, Cleveland, OH. April 12, 2013
  11. Mott, E.; Belle, V.; Welter, J.; Lennon, D.; Duesler, L.; Wang, M.; Busso, M.; Bensusan, J.; Fisher, J.; and Dean, D.: Additive manufacturing of poly (propylene fumarate) scaffolds and bioreactor pre-culturing of canine mesenchymal stem cells for cranial tissue engineering. 4th Annual National Center for Regenerative Medicine scientific retreat. Cleveland, OH November 12, 2012
  12. Larson, B.L.; Wu, P.B.; Estes, B.T.; Moutos, F.T.; Guilak, F.; Welter, J.F.; Langer, R.; and Freed, L.E.: “3D-woven poly (?-caprolactone) (PCL) with human mesenchymal stem cells (hMSCs): differentiation and integration with native bone in vivo” MRS 2012
  13. Welter, J.F.; Abdalian, S.; and Mansour, J.M.: Feasibility of using M-mode ultrasound imaging for cartilage tissue engineering quality control. BMES 2012
  14. Chou, C.L.; Rivera, A.L.; Caplan, A.; Goldberg, V.; Welter, J.F.; and Baskaran, H.: Multiscale approach to stem cell-based chondrogenesis for cartilage repair. ICRS; Montréal, PQ, 2012
  15. Belle, V.; Wallace, J.; Welter, J.; Lennon, D.; Fisher, J.; Wang, M.; and Dean, D.: Bioreactor pre-culturing of human and canine mesenchymal stem cells on poly(propylene fumarate) bone scaffolds prepared by additive manufacturing. TERMIS NA 2011 (accepted)
  16. Sarkar, S.; Bustard, B.; Welter, J.F.; and Baskaran, H.: A Combined Experimental and Theoretical Approach to Model Cell-Cell Interactions In Cancer Cell Migration. AIChE, Minneapolis, MN, October 16 – 21, 2011
  17. Chou, C.-L.; Rivera, A.L.; Welter, J.F., and Baskaran, H.: Micrometer Scale Guidance of Mesenchymal Stem Cells to Form Structurally Oriented Cartilage Extracellular Matrix. AIChE, Minneapolis, MN, October 16 – 21, 2011
  18. Correa, D.; Welter, J.F.; Duesler, L.; and Caplan, A.I.: Fibroblast growth factors 18 and 9 regulate chondrogenic differentiation of human mesenchymal stem cells. OARSI World Congress on Osteoarthritis, San Diego, CA, September 15 – 18, 2011
  19. Welter, J.F.; Citak, M.; Baskaran, H.; Caplan, A.I.; Goldberg, V.M.; and Mansour, J.M.: Does acoustic homogeneity correlate with tissue quality in engineered cartilage? OARSI World Congress on Osteoarthritis, San Diego, CA, September 15 – 18, 2011
  20. Chou, C.L.; Rivera, A.L.; Caplan, A.; Goldberg, V.; Welter, J.F.; and Baskaran, H.: Microscale guidance for optimal human mesenchymal stem cell-based chondrogenesis. OARSI World Congress on Osteoarthritis, San Diego, CA, September 15 – 18, 2011
  21. Welter, J.F.; Yuan, L.; Lim, S.; Molter, J.; Duesler, L.; Caplan, A.I.; and Lee, Z.: Real time imaging of reporter gene expression in differentiating human mesenchymal stem cells. BMES, Hartford, CT, October 12 – 15, 2011
  22. Citak, M.; Baskaran, H.; Caplan, A.I.; Mansour, J.M.; and Welter, J.F.: acoustic homogeneity as a quality measure in tissue engineered cartilage. BMES, Hartford, CT, October 12 – 15, 2011
  23. Chou, C.L.; Rivera, A.L.; Caplan, A.; Goldberg, V.; Welter, J.F.; and Baskaran, H.: Microscale guidance effect on stem cell based chondrogenesis for cartilage repair. BMES, Hartford, CT, October 12 – 15, 2011
  24. Sarkar, S.; Bustard, B.L.; Welter, J.F.; and Baskaran, H.: Combined experimental and mathematical approach to study microfabrication-based cell migration. BMES 2011 BMES, Hartford, CT, October 12 – 15, 2011
  25. Bükülmez, H.; Bartels, C.; Nanda, K.; Haqqi, T.M.; and Welter, J.F.: Cartilage protective effects of C-type natriuretic peptide over-expression in a K/BxN TCR arthritis model. ACR/ARHP 2011 Pediatric Rheumatology Symposium (PRSYM) Miami, FL, June 2 – 5, 2011.
  26. Dean, D.; Penick, K.J.; Anka, A.; Lennon, D.P.; Caplan, A.I.; and Welter, J.F.: Optimization of canine MSC osteogenesis by timed growth factor combinations. TERMIS-NA 2010
  27. Abrahamsson, C.K; Yang, F.; Park, H.; Brunger, J.M.; Valonen, P.K.; Langer, R.; Welter, J.F.; Caplan, A.I; Guilak, F.; Freed, L.E.: Influence of medium supplements on chondrogenesis and osteogenesis of collagen-embedded hMSCs on 3D-woven scaffolds. Gordon Research Conference on Musculoskeletal Biology and Bioengineering, 2010
  28. Chou, C.-L.; Rivera, A.L.; Penick, K.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Microscale guidance and its effect on human mesenchymal stem cell alignment and chondrogenesis. BMES 2010.
  29. Penick, K.J.; Baskaran, H.; Berilla, J.A.; and Welter, J.F.: Measuring glucose consumption by chondrogenically differentiating mesenchymal stem cells. BMES 2010.
  30. Richey, T.; Smith, M.; Thanoo, B.; Penick, K.J.; and Welter, J.F: Microsphere-based delivery of betamethasone to differentiating human mesenchymal stem cells. BMES 2010
  31. Walker, J.; Mansour, J.M.; Caplan, A.I.; Goldberg, V.M.; and Welter, J.F.: Poroelastic material properties of hydrogels and cartilage evaluated using ultrasound. BMES 2010
  32. Welter, J.F.; Solchaga, L.A.; Penick, K.J.; Leahy, P.; Caplan, A.I.; and Goldberg, V.M.: Gene expression changes associated with chondrogenic differentiation of human mscs. OARSI 2010
  33. Chou, C.-L.; Rivera, A.L.; Penick, K.J.; Caplan, A.I.; Goldberg, V.M.; Welter, J.F.; and Baskaran, H.: Microscale guidance and its effect on human mesenchymal stem cell alignment and chondrogenesis. OARSI 2010
  34. Bükülmez, H.; Haqqi, T.; Khan, F.; Welter, J.F.; and Murakami, S.:.Role of c-type natriuretic peptide (cnp) in osteogenesis and treatment of osteoporosis. OARSI 2010
  35. Walker, J.; McKee, A.; Berilla, J.; Baskaran, H.; Mansour, J.; and Welter, J.F.: Nondestructive ultrasonic evaluation of mechanical properties of agarose gels. ORS 2010
  36. Chou, C.-L.; Rivera, A.L.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented extracellular matrix. ORS 2010
  37. Shao, Y.; Wang, L.; Welter, J.F.; and Ballock, R.T.: Primary cilia are required for ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. ORS 2010
  38. McKee, A.; Mansour, J.M.; and Welter, J.F.: Noninvasive evaluation of mechanical properties of agarose gels using ultrasound technology. BMES 2009
  39. Berilla, J. and Welter, J.F.: Time-constant based fluorescent oxygen sensor. BMES 2009
  40. Welter, J.F.; Pelyak, M.R.; Penick, K.J.; Solchaga, L.A.; and Goldberg, V.M.: Extracellular matrix deposition by chondrogenically differentiating human mesenchymal stem cells is enhanced by macromolecular crowding. OARSI World Congress on Osteoarthritis, Montréal, PQ Canada September 9-13, 2009
  41. Pelyak, M.; Penick, K.; Cheung, H.-M.; and Welter, J.: Accelerated MSC extracellular matrix deposition through dextran sulfate, polystyrene, and hyaluronic acid. MSC2009, August 17-19, 2009
  42. Chou, C.-L.; Rivera, A.L.; Welter, J.F.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented extracellular matrix. AICHE 2009 (Accepted)
  43. Berilla, J. and Welter, J.F.: Oxygen sensors for bioreactor monitoring. Proceedings of the 2009 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2009
  44. McKee, A.M.; Mansour, J.M.; and Welter, J.F.: Noninvasive evaluation of mechanical properties through the use of ultrasound technology. Proceedings of the 2009 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2009
  45. Pelyak, M.; Penick, K.; Cheung, H.M.; and Welter, J.F.: Accelerated MSC extracellular matrix deposition through dextran sulfate polystyrene, and hyaluronic acid. Proceedings of the 2009 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2009
  46. Welter, J.F.; Solchaga, L.A.; Leahy, P.; Penick, K.J.; Caplan, A.I.; Goldberg, V.M.: Gene expression patterns during chondrogenic differentiation of human MSCs. 55th Annual Meeting of the Orthopædic Research Society, Las Vegas, NV, February, 2009. 924.
  47. Pelyak, M.R.; Penick, K.J.; Berilla, J.A.; Solchaga, L.A.; and Welter, J.F.: Macromolecular crowding accelerates extracellular matrix deposition by differentiating MSCs. 55th Annual Meeting of the Orthopædic Research Society, Las Vegas, NV, February, 2009. 914.
  48. Valonen, P.K.; Moutos, F.T.; Kusanagi, A.; Moretti, M.; Diekman, B.O.; Welter, J.F.; Caplan, A.I.; Guilak, F.; and Freed, L.E.: In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D woven poly(?-caprolactone) scaffolds. 55th Annual Meeting of the Orthopædic Research Society, Las Vegas, NV, February, 2009. 934.
  49. Shao, Y.; Wang, L.; Welter, J.; Ballock, R.T.; Leiferman, E.; and Noonan, K.: Mechanical forces modulate indian hedgehog signaling in vitro and in vivo. 55th Annual Meeting of the Orthopædic Research Society, Las Vegas, NV, February, 2009. 993
  50. Welter, J.F.; Solchaga, L.A.; Leahy, P.; Penick, K.J.; Caplan, A.I.; Goldberg, V.M.: Database of gene expression patterns during chondrogenic differentiation of human MSCs. OARSI 2008 (accepted).
  51. Baskaran, H.; Kienitz, B. L.; Liang, W.-H.; Penick, K.; Welter, J. F.: Optimizing collagen-GAG scaffolds for tissue engineering applications. OARSI 2008 (accepted).
  52. Berilla, J and Welter, J.F.: Local thickness measurements in engineered cartilage using image analysis. BMES meeting 2008, (accepted)
  53. Berilla, J and Welter, J.F.: Image analysis algorithm for measuring local thickness in engineered cartilage. Proceedings of the 7th Annual meeting workshop of the Midwestern Tissue Engineering Consortium, April 11-12, University of Cincinnati, Cincinnati, OH. 2008:nnn
  54. Berilla, J and Welter, J.F.: Image analysis algorithm for measuring local thickness in engineered cartilage. Research ShowCase2008
  55. Shao, Y.Y.; Welter, J.F.; Wang, L.; and Ballock, R.T.: Response of growth plate chondrocytes to hydrostatic loading in vitro. 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 638, March 2-5, 2008.
  56. Welter, J.F.; Baskaran, H.; Solchaga, L.A.; Penick, K.; and Berilla, J.: Aggregate formation dynamics as a biomarker for chondrogenic potential of mesenchymal stem cells. BMES 2007 P5.166
  57. Welter, J.F.; Baskaran, H.; Solchaga, L.A.; Penick, K.; and Berilla, J.: Aggregate formation dynamics as a biomarker for chondrogenic potential of mesenchymal stem cells. MSC2007, August 27-29, 2007:224
  58. Shao, Y.; Welter, J.; Wang, L.; and Ballock, T.: Hydrostatic loading of growth plate chondrocytes. ASBMR 2007 Journal of Bone and Mineral Research, 22S1:S156
  59. Berilla, J.; Penick, K.; Solchaga, L.; and Welter, J.: Timing of aggregate formation as a biomarker for chondrogenic potential. Proceedings of the 6th Annual meeting workshop of the Midwestern Tissue Engineering Consortium, April 20-21, 2007
  60. Penick, K., Solchaga, L.A.; and Welter, J.F.: A simplified aggregate culture system to assess chondrogenic potential. Proceedings of the 6th Annual meeting workshop of the Midwestern Tissue Engineering Consortium, April 20-21, 2007
  61. Berilla, J.; Penick, K.; Solchaga, L.; and Welter, J.: Timing of aggregate formation as a biomarker for chondrogenic potential. Proceedings of the 2007 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2007:102
  62. Penick, K., Solchaga, L.A.; and Welter, J.F.: A simplified aggregate culture system to assess chondrogenic potential. Proceedings of the 2007 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2007: 284
  63. Berilla, J.; Penick, K.; Solchaga, L.; and Welter, J.: Timing of aggregate formation as a biomarker for chondrogenic potential. Proceedings of the 2007 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2007:72
  64. Penick, K., Solchaga, L.A.; and Welter, J.F.: A simplified aggregate culture system to assess chondrogenic potential. Proceedings of the 2007 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2007
  65. Davood, V.; Welter, J.F.; Jackowe, D.J.; George, J.E.; Wang, J.Y. and Fisher, J.P.: Loading Rapid-Prototyped, Tissue-Engineered Poly(propylene fumarate) Scaffolds for Bioreactor Culturing. Proceedings of the 2007 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2007
  66. Solchaga, L.A.; Penick, K.J.; Caplan, A.C.; Goldberg, V.M.; and Welter, J.F.: Transforming growth factor-beta 1 modulates lineage progression of human mesenchymal stem cell-derived chondrocytes. Transactions of the Orthopædic Research Society, 2007, 32:1504
  67. Welter, J.F.; Solchaga, L.A.; Berilla, J.A.; Anderson, R.; Penick, K.J.; Vinson, A.; and Baskaran, H.: Measuring and modelling substrate mass-transport and consumption during human mesenchymal stem cell-based cartilage tissue engineering. Transactions of the Orthopædic Research Society, 2007, 32:494
  68. Welter, J.F.; Baskaran, H.; Solchaga, L.A.; and Goldberg, V.: Modelling substrate mass-transport during mesenchymal stem cell-based cartilage tissue engineering OARSI World Congress on Osteoarthritis Prague, Czech Republic December 7-10, 2006
  69. Solchaga, L.A.; Penick, K.; Caplan, A.I.; Goldberg, V.M.; and Welter, J.F.: Transforming growth factor-beta 1 modulates lineage progression of human mesenchymal stem cell-derived chondrocytes. OARSI World Congress on Osteoarthritis Prague, Czech Republic December 7-10, 2006
  70. Welter, J.F.; Anderson, R.; Penick, K.; Solchaga, L.A.; and Baskaran, H.: Substrate mass-transport modelling during MSC-based chondrogenesis Biomedical Engineering Society meeting, Chicago, IL, October 11 – October 14, 2006
  71. Anderson, R.; Baskaran, H.; Berilla, J.; Solchaga, L.; Penick, K.; and Welter, J.: Modeling mass-transport during maturation of MSC-based tissue engineered cartilage. Proceedings of the 2006 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2006:133
  72. Baskaran, H.; Kienitz, B.; and Welter, J.: Suspension centrifugation for optimizing lyophilized collagen-gag scaffolds for tissue engineering. Proceedings of the 2006 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2006:63
  73. Solchaga, L.; Penick, K.J.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Regulation of hypertrophic differentiation of human mesenchymal stem cell-derived chondrocytes. Proceedings of the 2006 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2006:408
  74. Vinson, A.; Solchaga, L.; Penick, K.; Welter, J.F.; and Baskaran, H.: Assessment of mass transport limitations in mesenchymal stem cell-based spherical cartilage constructs. Proceedings of the 2006 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2006:42
  75. Anderson, R.W.; Baskaran, H.; Berilla, J.A.; Solchaga, L.A.; Penick, K.J.; and Welter, J.F.: Modeling substrate mass transport during the growth of an MSC-based cartilage construct. Proceedings of the 6th symposium of the International Cartilage Repair Society, San Diego, CA, 8 – 11 January 2006: P3-40
  76. Solchaga, L.A.; Penick, K.J.; Goldberg, V.M.; Caplan, A.I.; Welter, J.F.: Regulation of lineage progression of human mesenchymal stem cell-derived chondrocytes. Proceedings of the 6th symposium of the International Cartilage Repair Society, San Diego, CA, 8 – 11 January 2006: P4-51
  77. Berilla, J.A.; Solchaga, L.A.; Baskaran, H.; and Welter, J.F.: A modular bioreactor optimized for cartilage tissue engineering. Biomedical Engineering Society meeting, Baltimore, MD, September 28 – October 1, 2005, 277:15
  78. Berilla, J.A.; Solchaga, L.A.; Penick, K.; Baskaran, H.; and Welter, J.F.: A modular bioreactor system for cartilage tissue engineering. Proceedings of the Arthritis Research Conference, Atlanta, GA. 2005
  79. Solchaga, L.A.; Penick, K.; Porter, J.D.; Goldberg, V.M.; Caplan, A.I.; Welter, J.F.: FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. Proceedings of the Arthritis Research Conference, Atlanta, GA. 2005
  80. Baskaran, H.; Berilla, J.; Solchaga, L.; and Welter, J.F.: Mesenchymal stem cell-based cartilage tissue engineering. Proceedings of the Arthritis Research Conference, Atlanta, GA. 2005
  81. Burton, L.; Penick, K.; Welter, J.F.; Caplan, A.I.; Goldberg, V.M.; and Solchaga, L.A.: Fibroblast growth factor-2 enhances the chondrogenic differentiation of adult mesenchymal stem cells. Proceedings of the 2005 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2005:169
  82. Berilla, J.; Solchaga, L.A.; Penick, K.; Baskaran, H.; and Welter, J.F.: A modular bioreactor system for cartilage tissue engineering Proceedings of the 2005 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2005:324
  83. Baskaran, H.; Berilla, J.; Solchaga, L.; and Welter, J.F.: Mesenchymal stem cell-based cartilage tissue engineering Proceedings of the 2005 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2005:50
  84. Welter, J.F.; Solchaga, L.A.; Penick, K.; Baskaran, H.; Goldberg, V.M.; Caplan, A.I.; and Berilla, J.A.: A modular bioreactor system for cartilage tissue engineering. Transactions of the Orthopædic Research Society, 2005, 30(2):1771
  85. Wenger, R.; Welter, J.F.; Hans, M.G.; Malemud, C.J.: Hydrostatic pressure increases apoptosis in tissue-engineered cartilage-constructs. Osteoarthritis Cartilage 12 Supplement B, S73, 2004
  86. Baskaran, H.; Solchaga, L.; Berilla, J.; and Welter, J.: Mesenchymal stem cell based cartilage tissue engineering. American Institute of Chemical Engineers meeting, Austin, TX, November 7-12, 2004:75c
  87. Baskaran, H.; Solchaga, L.; Berilla, J.; and Welter, J.: Transport considerations in mesenchymal stem cell-based cartilage tissue engineering. Biomedical Engineering Society meeting, Philadelphia, PA, October 13-16, 2004, 971:44
  88. Welter, J.; Baskaran, H.; Berilla, J.; Penick, K.; Goldberg, V.; Mansour, J.; Caplan, A.; and Solchaga, L.: Expansion and differentiation environment modulates chondrogenesis in large tissue engineered constructs. Biomedical Engineering Society meeting, Philadelphia, PA October 13-16, 2004972:44
  89. Welter, J.; Baskaran, H.; Berilla, J.; Penick, K.; Goldberg, V.; Mansour, J.; Caplan, A.; and Solchaga, L.: Enhanced chondrogenesis in large tissue engineered constructs by modulation of growth and differentiation conditions. Proceedings of the 5th symposium of the International Cartilage Repair Society, Ghent, Belgium, May 26 – 29, 2004:625
  90. Baskaran, H.; Solchaga, L.; Berilla, J.; and Welter, J.: Assessment of mass transport limitations during cartilage tissue engineering. Proceedings of the 5th symposium of the International Cartilage Repair Society, Ghent, Belgium, May 26 – 29, 2004:653
  91. Baskaran, H.; Solchaga, L.A.; Berilla, J.; and Welter, J.F.: Assessment of mass transport limitations during cartilage tissue engineering. Proceedings of the 2004 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2004:212
  92. Solchaga, L.A.; Goldberg, V.M.; Mishra, R.; Caplan, A.I.; Penick, K.J.; and Welter, J.F.: FGF-2 enhances the mitotic and chondrogenic potentials of human adult mesenchymal stem cells. Proceedings of the 2004 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2004:447
  93. Welter, J.F.; Baskaran, H.; Berilla, J.; Penick, K.; Goldberg, V.M.; Mansour, J.; Caplan, A.I.; and Solchaga, L.: Modulation of growth and differentiation conditions enhances chondrogenesis in large tissue engineered constructs. Proceedings of the 2004 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2004:448
  94. Welter, J.F.; Baskaran, H.; Berilla, J.; Penick, K.; Mansour, J.; Caplan, A.I.; and Solchaga, L.: Modulation of growth and differentiation conditions enhances chondrogenesis in large tissue engineered constructs. Transactions of the Orthopædic Research Society, 2004, 29(2):719
  95. Baskaran, H.; Solchaga, L.A.; Berilla, J.; and Welter, J.F.: Assessment of mass transport limitations during cartilage tissue engineering. Transactions of the Orthopædic Research Society, 2004, 29(2):721
  96. Solchaga, L.A.; Goldberg, V.M.; Mishra, R.; Caplan, A.I.; and Welter, J.F.: FGF-2 modifies the gene expression profile of bone marrow-derived human mesenchymal stem cells. Transactions of the Orthopædic Research Society, 2004, 29(2):777
  97. Welter, J.F.; Penick, K.; Berilla, J.; Caplan, A.I.; Goldberg, V.M.; and Solchaga, L.A.: MSC-based tissue engineered cartilage: Effects of construct assembly method and perfusion rates. Proceedings of the Arthritis Research Conference, Keystone, CO. 2003:71
  98. Baskaran, H.; Solchaga, L.A.; Penick, K.; Berilla, J.; and Welter, J.F.: Substrate mass transport in tissue engineered cartilage. Proceedings of the Arthritis Research Conference, Keystone, CO. 2003:70
  99. Welter, J.F.; Solchaga, L.; and Berilla, J.: Design of a modular bioreactor system. Proceedings of the 2003 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2003:69
  100. Penick, K.; Berilla, J.; Solchaga, L.; and Welter, J.F.: On the use of Delrin® (acetal) in tissue culture. Proceedings of the 2003 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2003:41
  101. Baskaran, H.; Solchaga, L.A.; Penick, K.; Berilla, J.; and Welter, J.F.: Substrate mass transport in tissue engineered cartilage. Proceedings of the 2003 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2003:67
  102. Berilla, J.; Solchaga, L.; and Welter, J.F.: A multichannel fiberoptic spectrophotometer for monitoring bioreactor medium pH. Proceedings of the 2003 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2003:247
  103. Malemud, C.; Islam, N.; Haqqi, T.; Jepsen, K.; Kraay, M.; Welter, J.F.: and Goldberg, V.: Role of apoptosis in arthritis. Proceedings of the 2003 Research ShowCASE, Case Western Reserve University, Cleveland, OH. 2003:24
  104. Solchaga, L.A.; Goldberg, V.M.; Mansour, J.; Caplan, A.I.; and Welter, J.F.: Cartilage tissue engineering: In vitro generation of large cartilaginous constructs. Transactions of the Orthopædic Research Society, 2003, 28(2):944
  105. Welter, J.F.; Tognana, E.; Goldberg, V.M.; Caplan, A.I.; and Solchaga, L.A.: Assembly of large cell-scaffold composites for cartilage tissue engineering. Transactions of the Orthopædic Research Society, 2003, 28(2):949
  106. Solchaga, L.A.; Tognana, E.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Tissue engineered cartilage implants: in vitro chondrogenic pre-conditioning. Proceedings of the 4th symposium of the International Cartilage Repair Society, Toronto / CA, 15 – 18 June 2002:271
  107. Welter, J.F.; Tognana, E.; Mansour, J.; Goldberg, V.M.; Caplan, A.I.; and Solchaga, L.A.: Tissue engineered cartilage implants: in vitro chondrogenic preconditioning. Proceedings of the 2nd Annual workshop of the Midwestern Tissue Engineering Consortium, 2002:21
  108. Solchaga, L.; Tognana, E.; Goldberg, V.M.; Caplan, A.I.; and Welter, J.F.: Tissue engineered cartilage implants: optimizing construct assembly. Transactions of the Orthopædic Research Society, 2002, 27(1):483
  109. Welter, J.F.; Pradhan, S.; Tsurel, S.; and Berilla, J.: Modulation of the c-fos promoter activity by brief low amplitude strains: a role for ets transcription factors? Transactions of the Orthopædic Research Society, 2002, 27(2):522
  110. Tsurel, S.; Pradhan, S.; Berilla, J.; and Welter, J.F.: Response of osteoblasts to brief, low amplitude strains: modulation of c-fos promoter activity. Israel Orthopaedic Association, Tel Aviv, December 4-5, 2001. J. Bone Joint Surg., 84-B(Supll. III):316-317
  111. Solchaga, L.A.; Tognana, E.; and Welter, J.F.: Tissue engineered cartilage implants: optimizing construct assembly. Orthopædic Research Day, Case Western Reserve University, June 2001
  112. Berilla, J. and Welter, J.F.: Development of a Shear Sensor for Cell Culture Applications. Orthopædic Research Day, Case Western Reserve University, June 2001
  113. Pradhan, S.; Berilla, J.; Tsurel, S.; and Welter, J.F.: Response of osteoblasts to brief, low amplitude strains: Modulation of c-fos promoter activity. Orthopædic Research Day, Case Western Reserve University, June 2001
  114. Malemud, C.J.; Haqqi, T.M.; Jepsen, K.J.; Islam, N.; Kraay, M.; Welter, J.; and Goldberg, V.M.: Induction of apoptosis in human chondrocytes by hydrostatic pressure. Osteoarthritis and Cartilage 2001, 9(Supplement B):S8
  115. Pradhan, S.; Tsurel, S.; Berilla, J.; and Welter, J.F.: Response of the c-fos promoter to brief low amplitude strains in osteoblasts: a role for ets transcription factors? ASBMR 2001 J. Bone Miner. Res. 2001, 16(S1):S361
  116. Balasubramanian, S.; Agarwal, C.; Efimova, T.; Dubyak, G.; Banks, E.B.; Welter, J.F.; and Eckert. R.L.: Thapsigargin suppresses differentiation-dependent human involucrin promoter activity by reducing CCAAT/enhancer-binding protein – DNA binding. 62nd Annual Meeting of the Society for Investigative Dermatology, Washington, DC, May, 2001
  117. Tsurel, S. and Welter, J.F.: Physiological levels of mechanical strain modulate osteoblast differentiation in vitro. Orthopaedic Research Day, Case Western Reserve University, January 2000
  118. Islam, N.; Islam, S.; Haqqi, T.; and Welter, J.F.: EGCG inhibits chondrocyte apoptosis. Orthopædic Research Day, Case Western Reserve University, January 2000
  119. Welter, J.F.; Islam, N.; Islam, S.; and Haqqi, T.M.: EGCG – a constituent of green tea – inhibits chondrocyte apoptosis. Transactions of the Orthopædic Research Society 2000, 25(2):907
  120. Agarwal, C.; Effimova, T.; Welter, J.F.; Crish, J.F.; and Eckert, R.L.: CCAAT/Enhancer binding proteins – required regulators of human involucrin promoter activity. Journal of Investigative Dermatology 1999, 112(4):549
  121. Effimova, T.; LaCelle, P.T.; Welter, J.F.; and Eckert, R.L.: Regulation of human involucrin promoter activity via a specific MAPK signal transduction cascade. Journal of Investigative Dermatology 1999, 112(4):549
  122. Effimova, T.; LaCelle, P.T.; Welter, J.F.; and Eckert, R.L.: Regulation of human involucrin promoter activity by a PKC, RAS, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. Proceedings of the AACR 1999, 40:364
  123. Tsurel, S.; Goldberg, V.M.; and Welter, J.F.: The response of human mesenchymal stem cells to mechanical strains changes as a function of differentiation state. Transactions of the Orthopædic Research Society, 1999, 24(2):628
  124. Banks, E.B.; Crish, J.F.; Welter, J.F.; and Eckert, R.L.: Characterization of human involucrin promoter distal regulatory region transcriptional activator elements – a role for SP1 and AP1 binding sites. Journal of Investigative Dermatology 1998, 110(4):604
  125. Efimova, T.; Banks, E.B.; LaCelle, P.T.; Welter, J.F.; and Eckert, R.L.: Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK, and Activator Protein-1 signal transduction pathway. Journal of Investigative Dermatology 1998, 110(4):604
  126. Welter, J.F.; Agarwal, C.; Efimova, T.; and Eckert, R.L.: The human involucrin promoter proximal regulatory region – a role for C/EBP, AP1, ets, and AP2 binding sites. Journal of Investigative Dermatology 1998, 110(4):603
  127. Welter, J.F. and Eckert, R.L.: Functional characterization of the human involucrin proximal promoter regulatory region – Effects of CAAT enhancer binding protein, activator protein – 1, ETS factors and activator protein – 2. Journal of Investigative Dermatology 1997, 108(4):630
  128. Welter, J.F.; Robinson, N.A.; Bright, G.R.; and Eckert, R.L.: Immunocytochemical localization of AP1 family transcription factors in normal human keratinocytes cultured under serum free conditions. Journal of Investigative Dermatology 1997, 108(4):630
  129. Robinson, N.A.; Lapic, S.; Welter, J.F.; and Eckert, R.L.: S100c, s100a10, annexin I, desmosomal proteins, sprs, plasminogen activator inhibitor – 2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. Journal of Investigative Dermatology 1997, 108(4):552
  130. Welter, J.F.; Gali, H.U.; Crish, J.F.; and Eckert, R.L.: Regulation of the human involucrin promoter by POU domain proteins. Journal of Investigative Dermatology 1996, 106(4):907
  131. Banks, E.B.; Crish, J.F.; Welter, J.F.; and Eckert, R.L.: Combinatorial regulation of human involucrin promoter activity by modulator, silencer and enhancer elements. Journal of Investigative Dermatology 1996, 106(4):838
  132. Welter, J.F. and Eckert, R.L.: Expression of activator protein-1 (AP-1) family members in the human epidermis and in cultured keratinocytes. Journal of Investigative Dermatology 1995, 104(4):674
  133. Welter, J.F.; Crish, J.F.; Agarwal C.; and Eckert R.L.: Regulation of human involucrin promoter function by activator protein-1 (jun/fos) and phorbol myristate acetate. Journal of Investigative Dermatology 1994, 102(4):577
  134. Brown, K.L.B. and Welter, J.F.: A comparison of vascularized and conventional bone grafts for bridging large bone defects. In: Proceedings of the Fourth International Symposium on Limb Salvage in Musculoskeletal Oncology. Springer Verlag
  135. Welter, J.F. and Brown, K.L.B.: A comparison of free vascularized and conventional fibular grafts for large defects in weight bearing bones. In: Aebi, M. and Regazzoni, P. (eds) Proceedings of the First International Symposium on Bone Transplantation: 1989, pp. 86 – 87. Springer Verlag
  136. Welter, J.F. and Brown, K.L.B.: A comparison of free vascularized and conventional fibular grafts for large defects in weight bearing bones. Orthopædic Transactions 1987, 11(2):291 – 292
  137. Welter, J.F.; Kornacki, J.B.; and Brown, K.L.B.: A comparison of free vascularized and conventional fibular grafts for large defects in weight bearing bones. Transactions of the Orthopædic Research Society, 1987, 22(1):115
  138. Brown, K.L.B.; Kornacki, J.B.; Welter, J.F.; Poole, A.R.; and Cruess, R.L.: The effects of weightbearing on the growth of heterotopically transplanted free vascularized epiphyseal grafts in dogs. Orthopædic Transactions 1986, 10(2):241 – 242
  139. Brown, K.L.B.; Kornacki, J.B.; Welter, J.F.; and Cruess, R.L.: The effects of weight bearing on the growth of heterotopically transplanted free vascularized epiphysial grafts in dogs. Transactions of the Orthopædic Research Society, 1986, 21(1):52

Invited Presentations:

  • Canine and Human Mesenchymal Stem Cells, Growth Factors, Bioreactors, and Animal Model Studies. External Advisory Board and Co-Investigators meeting of NIH Grant R01-DE013740, Strength and Resorption of Biodegradable Skull Implants. July 21, 2011
  • Intra-articular delivery of injectable sustained-release drug formulations. NCRM Retreat, November 14, 2011
  • X marks the spot. Spatial and temporal distribution of Type X collagen in engineered cartilage. MSCs Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, November 15, 2010
  • Canine Mesenchymal Stem Cells, Growth Factors, Bioreactors, and Toxicity. External Advisory Board and Co-Investigators meeting of NIH Grant R01-DE013740, Strength and Resorption of Biodegradable Skull Implants. June 2, 2010
  • Crowding MSCs Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, February 1, 2010.
  • Cartilage tissue engineering. EBME 325 guest lecture, Case Western Reserve University, Cleveland, OH, November 30, 2009
  • Optimizing MSC differentiation; CTTE-2009 “Cell-Based Therapies and Tissue Engineering” short course, Case Western Reserve University, Cleveland, OH, May 25, 2009
  • How Thick Is That? Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, March 23, 2009
  • Bioreactors for Cartilage Tissue Engineering; CTTE-2008 “Cell-Based Therapies and Tissue Engineering” short course, Case Western Reserve University, Cleveland, OH, May 26, 2008
  • Optimizing MSC differentiation; CTTE-2008 “Cell-Based Therapies and Tissue Engineering” short course, Case Western Reserve University, Cleveland, OH, May 26, 2008
  • Case study: Cartilage tissue engineering. EBME 325 guest lecture, Case Western Reserve University, Cleveland, OH, November 15, 2007
  • Probing MSC differentiation. Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, October 29, 2007
  • Heavy breathers: oxygen consumption in cartilage tissue engineering. Case Study: Cartilage Tissue engineering.
  • Case study: Cartilage tissue engineering. EBME 325 guest lecture, Case Western Reserve University, Cleveland, OH, November 9, 2006
  • Bioreactors for mesenchymal stem cell differentiation; CTTE-2006 Cell-Based Therapies and Tissue Engineering short course, Case Western Reserve University, Cleveland, OH, May 26, 2006
  • Cartilage tissue engineering. Department of Biology seminar series. Case Western Reserve University, Cleveland, OH. May 4, 2006
  • Bioreactors for mesenchymal stem cell differentiation; CTTE-2005 Cell-Based Therapies and Tissue Engineering short course, Case Western Reserve University, Cleveland, OH, June 1, 2005
  • Surface characteristics of trabecular metal bone implants. Orthopædic and Related Research Seminar series, Case Western Reserve University, Cleveland, OH, May 26, 2005
  • Surface characteristics of bone implants. Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, November 29, 2004
  • More cartilage tissue engineering – Design of a hydrostatic loading bioreactor. Skeletal Research Center seminar series, Case Western Reserve University, Cleveland, OH, March 15, 2004
  • Cartilage tissue engineering. Skeletal Research Center seminar series. Case Western Reserve University, Cleveland, OH. March 10, 2003
  • Cartilage tissue engineering. Orthopædic grand rounds, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH. February 22, 2003.
  • Cartilage tissue engineering. Issues and approaches. CWRU/CCF musculoskeletal research seminar series. Case Western Reserve University, Cleveland, OH, December 12, 2002
  • Cartilage tissue engineering: Presented to the Arthritis Foundation Board of Trustees, Cleveland, OH, October 29, 2002
Page last modified: July 31, 2014